Along with acting, Brooke has expressed interest in filmmaking. She's directed a short film and a documentary prior to her job as a regular on Grey's Anatomy.
Brooke is 5 feet 10.5 inches tall.
Brooke attended and graduated from the American Academy of Dramatic Arts.
Brooke shared an apartment with singer Jeff Buckley before he recorded his album Grace.
Brooke is the daughter of retired public relations specialist Lois Smith and of publisher Gene Smith.
Brooke attended Tappan Zee High School.
Brooke's godfather is Robert Redford.
Brooke's daughter Fanny was born in 2003 and in 2008 Brooke and her husband adopted their second daughter, a baby girl Lucy Dinknesh Lubensky, from Ethiopia.
Brooke married Russian cinematographer Steve Lubensky on January 6, 1999. The couple have two children together.
Brooke wears a dress size 10-12, but mostly 12.
Brooke was in labor for 78 hours with her daughter Fanny and refused an epidural the entire time.
Brooke was nominated in 2008 for a SAG Award along with her Grey's Anatomy classmates for Outstanding Performance by an Ensemble in a Drama Series.
Brooke had to gain twenty-five pounds for her role in the 1991 film, The Silence of the Lambs.
Brooke: (On the idea of becoming a series regular on ABC hit show Grey's Anatomy ) It's one of those things you, you know, I wouldn't allow myself to think that that would happen because, you know, I would just be disappointed.
Brooke: (On kissing Grey's Anatomy co-star Sara Ramirez) Well, you know it was pretty good. She's a great kisser, what can I say? Very soft lips, she's a very attractive woman, you know. I mean, who wouldn't want to kiss her?