An entertainer on a cruise ship is killed, and Castle and Beckett investigate while trapped on the ship with the murderer.
The team must stop a runaway train with Paige and Ralph aboard. Meanwhile, Toby competes in his first boxing match in an attempt to impress Happy.
Paige Finney calls Ray to protect a quarterback; Lena considers quitting.
Information about Huck's past is revealed; not realizing that someone could be watching, Fitz and Olivia have an emotionally charged conversation; Cyrus becomes increasingly suspicious of Jake.
Lindsay becomes injured during the attempted murder of a political candidate. The CSI team race to catch the shooter and the events in the aftermath lead to a child's death.
Annie is confronted with a decision that could force her to reveal her work as an escort when Dixon gets arrested in connection with a fire at a sorority house. Adrianna and Silver try to put their troubled past behind them, which turns into a disaster for Greg and Silver's relationship. Vanessa helps organize a re-launch party for Liam's bar, where The All-American Rejects perform.moreless
The residents are starting their fifth and final year. April struggles with her new role as Chief Resident. Meredith must face the aftermath of her choices.
This is the first hour of a 2-hour season premiere. Two episode entries have been created. The 10pm EST marker will mark to beginning of the second episode.moreless