Clark Gregg first attended Ohio Wesleyan University, but subsequently transferred to New York University. He received his BFA in drama from the university's Tisch School of the Arts in 1986.
In 1988, Clark Gregg made his feature film debut in the Edgar nominated Things Change, in a small part as "the stage manager". Gregg was directed by one of his mentors, David Mamet, and joined in the cast by another mentor, William H. Macy.
(on the possibility of fans recognizing him by name because of his starring role in "The New Adventures of Old Christine")Clark Gregg: ...actually, I kind of like 'it's that guy'-ness.
(on being recognized or not, prior to starring in "The New Adventures of Old Christine")Clark Gregg: Sometimes, lately, people will recognize me from some movie or something. But for years, it's just been, people think they went to high school or something with me.
(on playing the role of Hank/Henrietta, transexual-in-transition, in "The Adventures of Sebastian Cole")Clark Gregg: I didn't want to play a cross-dressing male. With Henrietta, what you see is what you get. The cool irony that [director Tod Williams]came up with is that the person who's making the most radical life choices--and who some people might consider, in a simplistic sense, the most flaky--is also the most solid, dependable person in Sebastian's life. I felt like any tremendous level of artifice would only impede Henrietta's ability to be a good parent.