With Ghost Rider running out of time and half of the team the gone, the others try to deal with the Darkhold.
Robbie's back story is revealed as Coulson and his team fight for their lives.
S.H.I.E.L.D. infiltrates a high-security prison to find out more about the Darkhold, while Ghost Rider fights to emerge from Robbie.
While Daisy teams up with a figure from the past to bring down the Watchdogs, Coulson and Mack square off against Ghost Rider.
While Coulson, Fitz, and Mack try to identify who is responsible for a series of blackouts, Jemma and Holden try to save Melinda, while Daisy learns more about Robbie and Gabe.
Daisy goes back to confront Robbie, suspecting a connection between the mysterious "Ghost Rider," the ghosts, and the gangs allying together. Meanwhile, Coulson meets with the new Director while Melinda's condition deteriorates.
S.H.I.E.L.D. is legitimized again, and Coulson and Mack lead the field investigations while Melinda trains a new strike team, and Fitz and Jemma continue their relationship.
Coulson and his team take on Hive before he can set off the warhead and transform the world's population into his Inhuman slaves. However, one team member will sacrifice themselves to stop the Inhuman leader.moreless
Hive's master plan is completely revealed, forcing S.H.I.E.L.D. into action.
Talbot demands that Coulson register the S.H.I.E.L.D. Inhumans, and is less than thrilled to learn about the threat of Hive. Meanwhile, Daisy helps Lincoln to escape the base so that he can join her.moreless
While a S.H.I.E.L.D. strike team goes after Hive, Mack tries to rescue Daisy before it's too late. Meanwhile, Fitz and Jemma create an anti-toxin against Hive's parasites, and Lincoln insists on testing it on himself.moreless
Fitzsimmons tries to find a way to stop Hive as he continues to recruit Inhumans to his side.
Daisy and her team of Inhumans rescue Coulson and his people from Hydra. However, they soon learn that despite their apparent success, a traitor within the team threatens to tear S.H.I.E.L.D. apart from the inside.moreless
Gideon wrestles with his past as Hive calls a meaning of Hydra's inner council. Meanwhile, Daisy and Lincoln look for a former Afterlifer with information on Hive, while the others investigate Hydra's newest business acquisition.moreless
Daisy gets a terrifying glimpse into the future and S.H.I.E.L.D. tries to prove her vision isn't set in stone.
A new group, the Watchdogs, go public and destroy an ATCU facility as they declare on the war on the Inhumans and the ATCU. Meanwhile, Mack tries to spend some downtime with his brother.moreless
Bobbi and Hunter follow Gideon to a compound in Russia, and discover what he has in mind for the Inhumans in Russia.
President Ellis sponsors an international symposium on the Inhuman problem, and Coulson and Talbot must attend it. Along the way, they try to find Malick's inside man. Meanwhile, a foe from the past makes a return, and the team find a potential vaccine against Terrigenesis.moreless
Coulson and President Ellis come to an arrangement, and Coulson begins the hunt for Malick. Meanwhile, Daisy leads a team to Bogota to track down a rogue Inhuman, and discovers that there's more involved than they first thought.moreless
On the alien planet, Coulson hunts down Grant to get revenge for Rosalind's death. Meanwhile on Earth, the team secure the portal in the hopes of bringing their comrades home.
Coulson swears to do whatever it takes to bring in Grant, after the rogue agent strikes at someone close to Coulson. Meanwhile, Gideon captures Jemma and Fitz, and Mack convinces Joey and Lincoln to join the new team of Inhumans.moreless
While Coulson's team infiltrate the ATCU base, Coulson interrogates Rosalind about what they discover during the break-in. Meanwhile, Gideon explains to Grant the true origins of Hydra.
While Fitz helps Jemma recover the information from her phone that could help the team open the portal, Coulson and Rosalind join forces to track down Andrew after Lincoln comes in out of the cold to confirm that Andrew is Lash.moreless
Coulson accompanies Rosalind to the ATCU facility, while Daisy, Mack, and Lance run surveillance on Banks. Meanwhile, Melinda takes Bobbi with her to track down the man who attacked Andrew.
Jemma tells Fitz about what happened to her on the alien planet... and the man who helped her survive.
While Coulson and Rosalind launch their first joint operation to find Lash, Melinda worries that Lance is too invested in his attempts to kill Grant.
While Mack and Daisy try to get to Lincoln before the ACTU does, Lance and Melinda try to get close to Grant. Meanwhile, Fitz nurses Jemma back to health after her rescue.
The team turns to Elliott for help figuring out where the monolith took Jemma, and he leads them to a castle in Gloucestershire. Meanwhile, Lance prepares to hunt down Grant and turns to Melinda for help.moreless
While Fitz tries to get Jemma back, Coulson and Skye discover that another organization is also hunting Inhumans.
Coulson realizes that Jiaying intends to set off a war, but tries to avoid launching a counter attack for fear of hurting Skye. Meanwhile, Skye appeals to Jiaying to reconsider, and Grant tries to give Kara closure.moreless