He is the son of Charles Guggenheim and his mother is Marion Guggenheim and is the brother of Grace Guggenheim and Jonathan Guggenheim.
He is a former member of the all-male a cappella group, "The Brown Derbies".
He attended Brown University.
He has three children. His son is Miles William (b. November 11, 1997) and his two daughter are Stella Street (b. March 19, 2001) and Agnes Charles (b. June 18, 2006).
He is married with actress Elisabeth Shue since 1994.