Lena is arrested for helping break Metallo and Lillian Luthor out of prison. While the evidence seems stacked against her, Kara refuses to believe her friend is guilty and fights to clear Lena's name.moreless
Supergirl ends up seriously injured during an attack on National City by a kryptonite-powered villain; and Superman puts the blame for his cousin getting hurt on Hank, because the kryptonite was stolen from the DEO. Meanwhile, Kara's first day at her new job doesn't go as planned after she meets her new boss, Snapper Carr.moreless
Superman pays his cousin Supergirl a visit, and they team up to determine if Lex Luthor's sister Lena was behind a space shuttle crash. Meanwhile, the inhabitant of the landing pod is revealed.moreless
Sam and Dean travel to a town in Colorado where a fog is spreading the same madness that they ran into when they first encountered Amara. Meanwhile, Metatron is summoned to a meeting with God.moreless
Liv eats the brain of a mental patient to find out how he died, and suffers from the same paranoid delusions. Meanwhile, Major tracks Blaine and Julien to Meat Cute, and Ravi and Peyton have their first date.moreless
As Bullet wrestles with the truth, Sarah and Holder talk to the latest victim. Seward is confronted with his past.
Shawn is his usual suspicious self about the new person in Juliet's life. Only this time he takes it a step further. He suspects the friend of murder. Elsewhere, he spends quality time with Woody.moreless
Linden and Holder close in on the murderer. Richmond's campaign gets ready for Election Day. The Larsen family tries to salvage their lives and get back some sense of order.
Linden searches everywhere for the missing Holder. Stan decides to deals with things on his own. Richmond makes a return to City Hall.
Madison and Hauser look for Johnny McKee, the latest Alcatraz inmate to surface. He's a chemist with a vicious killer instinct. More details emerge about Madsen's grandfather, Tommy Madsen.
Magnus is asked to help broker a peace agreement between Caleb, a Hollow Earth insurgent leader, and the world's governments - an agreement whereby Abnormals would be permitted to settle on the surface. Preparing to take military action against the Abnormal forces, Addison "drafts" Will back into the federal government, further dividing Team Sanctuary.moreless