She voiced Maiev Shadowsong and a Night Elf Female in the video game World of Warcraft.
She voiced Joan Rivers in Queer Duck: The Movie.
Debi Mae West has voiced and cooperated with the Metal Gear Solid series multiple times, voicing in five of the games.
She voices Patty, Hannah, Jezebel and Bum in the video game Vampire: The Masquerade - Bloodlines.
She voiced Patricia in the game Neopets: The Darkest Faerie however she was credited as Debbie Mae West.
She voices Savory in the video game Steambot Chronicles. However, she is uncredited.
She voiced the Necromancer Queen and Female Deadite 1 in the video game Evil Dead: Regeneration.
Debi Mae West appeared as herself in Boys Up Unauthorized
She voiced Baransha and Reycom in the Zatch Bell: Mamodo Fury video game.
Debi played as Atropos in the video game God of War II.
She played as Himatsu from the Naruto OVA Mission: Protect the Waterfall Village!
She plays Meryl Silverburgh in Metal Gear Solid (Video Game).
She did a radio show called "The Other Side" by Joe Franks from 1999-2001.