Born in Glendale, CA, and raised in Massachusetts, Rupp knew that she wanted to be an actress at an early age. Her parents disagreed, and sent her to the University of Rochester in New York specifically because they didn't have a drama department. They later added a drama course, and she graduated in 1974. She then moved to New York and made her film debut in the 1988 Tom Hanks comedy Big. She is also known for playing Kitty Forman on the hit tv show That '70s Show
Debra currently resides in Los Angeles, CA.