While Jemma secures the Kree city, Skye is put into quarantine. Meanwhile the team carries out an operation against Hydra to eliminate the people who arranged Trip's death.
New threats to the Prison survivors arise while the Woodbury population readies for a new danger.
After witnessing an accident, Andrea and Michonne are introduced to a new community of survivors. As conflicts arise with their new acquaintances, a decision must be made.