In January 2009, Eliza went back and visited her old high school, Plymouth Regional in Plymouth, New Hampshire, and talked to the students about her experiences as an actress. She also gave advice to those who are aspiring to have a career in acting.
In 2009, Eliza was cast in the pilot of No Heroics, the US version of the 2008 British comedy, but the show was not picked up, paving the way for Coupe's promotion to a series regular in the ninth season of Scrubs.
She was first discovered by her manager Kirsten Ames, who is the producer of Aspen's U.S. Comedy Festival, in a workshop in 2004.
Eliza, who plays the recurring character Denise Mahoney on the ABC medical sitcom Scrubs, portrays the same role in the webisode series Scrubs: Interns found on the network's official website.
While in high school, Eliza portrayed Bonnie in the school production of Anything Goes and one of the Mundy sisters in Dancing at Lughnasa.
She is married to puppeteer and artist Randall Whittinghill.
Eliza has natural blonde hair and hazel eyes.
Coupe honed her skills at performing comedy sketches with the Groundlings Theater and Improv Olympics.
She won the Entertainment Weekly Breakout Award in the 2006 U.S. Comedy Arts Festival (USCAF) for the Live Performances category.
In July 2006, she was named as one of the 10 Comics to Watch by Variety.com.
Coupe starred in a one-woman show called The Patriot at the 2006 Aspen Comedy Festival. She also portrayed the role of a soldier in the all-female production of King Lear in 2003.
In 2006, Eliza played Allison in the short film The Day the World Saved Shane Sawyer.
In high school, Eliza used to keep a laminated picture of Justin Timberlake in her wallet and pretended he was her boyfriend.
Eliza Coupe: (in a 2006 interview) I think the terminology used in this industry is hilarious. I had a meeting the other day, and someone actually said in conversation, 'Cut to next week.' I looked around and was, like, what? Are we in a movie script right now?
Eliza Coupe: (on the characters she wrote for "The Patriot") They're the committee that lives in my head.
Eliza Coupe: (on writing and starring in a one-woman show) I didn't think anyone would probably write a better part for me than me, given the fact a lot of girls are trying to break into the business, so I did it myself.
Eliza Coupe: (advice to students who want to go into acting) Go to workshops. Learn what you can. There's always someone good giving a workshop.
Eliza Coupe: (in a 2006 interview) There are a lot of things -- I'm going to use an industry phrase -- 'in the mix' for me. I've gone out on six auditions in the last two days, and I've gotten callbacks on almost all of them.
Eliza Coupe: (after touring the country for the production of "King Lear") I thought, 'If I hear one more depressing Elizabethan, I'm going to lose it' -- I need to do something funny!