Erica was born in Calgary to a truck driver, Joel, and librarian, Gail. She grew up with an older brother and sister on a turkey farm in Three Hills, Alberta. After school, she moved to Vancouver to start her acting career, which has primarily included low-budget horror films and guest roles on sci-fi TV shows.
In 2004, Durance began her role as Lois Lane in the popular CW/WB series Smallville.
Erica married David Palffy on January 8, 2005.