Awards & Nominations:
- For Transamerica
• 2005 (W) - Best Actress, Ft. Lauderdale International Film Festival
• 2005 (W) - Best Actress, National Board of Review, USA
• 2005 (W) - Best Performance by an Actress in a Leading Role, Phoenix Film Critics Society Awards
• 2005 (W) - Outstanding Actress in a Motion Picture, Drama, Satellite Awards
• 2005 (W) - Best Actress, Southeastern Film Critics Association Awards
• 2005 (W) - Best Actress, Tribeca Film Festival
• 2005 (N) - Best Actress, Washington DC Area Film Critics Association Awards
• 2006 (W) - Best Actress, Bangkok International Film Festival
• 2006 (W) - Best Actress, Dallas-Fort Worth Film Critics Association Awards
• 2006 (W) - Best Performance by an Actress in a Motion Picture - Drama, Golden Globe Awards
• 2006 (W) - Best Female Lead, Independent Spirit Awards
• 2006 (W) - Breakthrough Performance Award, Palm Springs International Film Festival
• 2006 (W) - Best Actress, Vancouver Film Critics Circle
• 2006 (N) - Best Performance by an Actress in a Leading Role, Academy Awards
• 2006 (N) - Best Actress, Broadcast Film Critics Association Awards
• 2006 (N) - Best Actress, Chicago Film Critics Association Awards
• 2006 (N) - Best Actress, Online Film Critics Society Awards
• 2006 (N) - Outstanding Performance by a Female Actor in a Leading Role, Screen Actors Guild Awards
- For Desperate Housewives
• 2005 (W) - Outstanding Lead Actress in a Comedy Series, Emmy Awards
• 2005 (W) - Outstanding Actress in a Series, Comedy or Musical, Satellite Awards, tied with Mary-Louise Parker (Weeds)
• 2005 (W) - Outstanding Performance by an Ensemble in a Comedy Series, Screen Actors Guild Awards, shared with castmates
• 2005 (N) - Performance in a Comedy Series, Prism Awards
• 2005 (N) - Best Actress in a Series, Comedy or Musical, Satellite Awards
• 2005 (N) - Best Performance by an Actress in a Television Series - Musical or Comedy, Golden Globe Awards
• 2006 (W) - Outstanding Performance by an Ensemble in a Comedy Series, Screen Actors Guild Awards, shared with castmates
• 2006 (W) - Outstanding Performance by a Female Actor in a Comedy Series, Screen Actors Guild Awards
• 2006 (N) - Best Performance by an Actress in a Television Series - Musical or Comedy, Golden Globe Awards
• 2007 (N) - Best Performance by an Actress in a Television Series - Musical or Comedy, Golden Globe Awards
• 2007 (N) - Outstanding Lead Actress in a Comedy Series, Emmy Awards
• 2007 (N) - Best Actress in a Series, Comedy or Musical, Satellite Awards
• 2007 (N) - Outstanding Performance by a Female Actor in a Comedy Series, Screen Actors Guild Awards
• 2007 (N) - Outstanding Performance by an Ensemble in a Comedy Series, Screen Actors Guild Awards, shared with castmates
• 2008 (N) - Outstanding Performance by an Ensemble in a Comedy Series, Screen Actors Guild Awards, shared with castmates
• 2009 (N) - Outstanding Performance by an Ensemble in a Comedy Series, Screen Actors Guild Awards, shared with castmates
- For Other Works
• 1994/1995 (W) - OBIE Awards, for Cryptogram
• 2000 (N) - Best Actress in a Quality Comedy Series, Viewers for Quality Television Awards, for Sports Night
• 2000 (N) - Best Performance by an Actress in a Television Series - Musical or Comedy, Golden Globe Awards, for Sports Night
• 2004 (N) - Best Performance by an Actress in a Miniseries or a Motion Picture Made for Television, Satellite Awards, for Out of Order
• 2005 (N) - Performance in a TV Movie or Miniseries, Prism Awards, for Reversible Errors
• 2008 (N) - Performance in a Feature Film, Prism Awards, for Georgia Rule
(W) - Won
(N) - Nominated
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