John gets a visit from his devoutly Catholic parents. Meanwhile, Jane starts taking a certain medication to impress a guy, despite the unpleasant side effects.
Mulaney wonders why Jane dislikes all of his girlfriends; and Lou asks for help planning a dignified death.
John's neighbor Lapidus dies, and to honor him, John decides to use Lapidus' jokes for Lou's monologue.
Holly's new boyfriend, Paul, invites the guys to an amazing party, but Stuart begins to wonder how close Paul remains with his ex-wife.
Holly tries to help Stuart get back into the dating world. Meanwhile, Haskell tries to make his ex-wife jealous.
Charlotte and Wayne end up making an impulsive bet to see who can have the first one-night stand. Charlotte's target is a vegan firefighter while Wayne pursues a French-Israeli supermodel. The contest ends up pitting the guys against the girls with a surprising outcome.moreless