While Jemma secures the Kree city, Skye is put into quarantine. Meanwhile the team carries out an operation against Hydra to eliminate the people who arranged Trip's death.
Vanessa and Sir Malcolm face their worst nightmares while Ethan and Victor are confronted with their pasts.
The UCOS team reopens a unsolved murder case of pornographer Jim Hockney when his daughter's paternity test reveals that he was not her father. They try to track down the previous suspect for the crime, the victim's girlfriend jazz singer Angela Gold. Recently retired police officer Dan Griffin joins the team as Brian's replacement.moreless
Meanwhile, Jane befriends a young man while doing some charitable work on behalf of the local hospital, and Charlie Gimbert is asked to find a rather special clock for a customer.