Isabella was considered to play Mia in Pulp Fiction (1994) but turned the role down.
Isabella developed her own brand of cosmetics, Manifesto, in 1995.
Isabella was the exclusive spokesmodel for the international cosmetics company, Lancome, in both the United States and Europe, from 1982-1996.
At 14, she was bed ridden for 18 months due to sever scoliosis and then spent the next two years in a pelvic cast.
She can speak fluent in Italian, French and English.
She suffered from scoliosis (progressive curvature of the spine) and underwent surgery to correct it. She was in a body cast for a year.
She was scheduled to appear in the David Lean-directed "Nostromo" in 1991, before Lean died, and the production came to a halt.
She maintains a home in the village of Bellport, NY.
She was chosen by Empire magazine as one of the 100 Sexiest Stars in film history (#84). .
Isabella suffered from a spine injury which kept her bedridden for over a year when she was thirteen.
She was chosen by People magazine as one of the 50 Most Beautiful People in the world (1990).
She used to date Gary Oldman.
She is the twin sister of Isotta Rossellini, who is a professor of Italian Renaissance literature at Columbia University.
In a Tales from the Crypt (1989) episode, she spoofs her mother's Casablanca (1942) image.
Isabella divorced Martin Scorsese in 1983.
Isabella: (Commenting on the critics' response to her performance in "Blue Velvet") David Lynch came out of it a genius, and I came out of it a fat girl. I'm sorry that the only comment I get about the part is the way I look.
Isabella: But my mother loved The Elephant Man, and my father gave David Lynch a scholarship to study in Rome.
Isabella: If we are completely honest with ourselves, everyone has a dark side to their personalities.
Isabella: When David left me I became totally brokenhearted.
Isabella: In America, they are paranoid about ruining the reputations of people once they are dead and cannot answer back. They have this fascination which to me seems cruel and morbid. I do not want any part of it.
Isabella: I didn't want to become an actress because the competition with my mother would have been to much to live up to.
Isabella: But I don't really see myself as a role model. I'm not a dictator, or someone who wants to be adored!
Isabella: A lot of the advertisement is done by saying: first of all, have a complex about who you are.