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Isabella was considered to play Mia in Pulp Fiction (1994) but turned the role down.
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Isabella developed her own brand of cosmetics, Manifesto, in 1995.
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Isabella was the exclusive spokesmodel for the international cosmetics company, Lancome, in both the United States and Europe, from 1982-1996.
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At 14, she was bed ridden for 18 months due to sever scoliosis and then spent the next two years in a pelvic cast.
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She can speak fluent in Italian, French and English.
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She suffered from scoliosis (progressive curvature of the spine) and underwent surgery to correct it. She was in a body cast for a year.
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She was scheduled to appear in the David Lean-directed "Nostromo" in 1991, before Lean died, and the production came to a halt.
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She maintains a home in the village of Bellport, NY.
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She was chosen by Empire magazine as one of the 100 Sexiest Stars in film history (#84). [1995].
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Isabella suffered from a spine injury which kept her bedridden for over a year when she was thirteen.
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She was chosen by People magazine as one of the 50 Most Beautiful People in the world (1990).
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She used to date Gary Oldman.
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She is the twin sister of Isotta Rossellini, who is a professor of Italian Renaissance literature at Columbia University.
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Isabella divorced Martin Scorsese in 1983.