In 2008 James appeared on stage in "How Cissy Grew" at the El Portal Forum Theatre in North Hollywood. His wife, Erin J. O'Brien, co-starred in the play.
James starred in the 2007 TV movie Custody, he played John Sullivan.
James was nominated in 2008 for a SAG Award along with his Desperate Housewives castmates for Outstanding Performance by an Ensemble in a Comedy Series.
James was chosen as one of People Magazine's Sexiest Men Alive for 2007.
James describes his first wife as his own 'desperate housewife', saying, "she was desperate to get away from me!"
James threw out the ceremonial first pitch before the Minnesota Twins baseball game against the Atlanta Braves in Minneapolis. (June 2007)
James is a Southern Baptist.
Whenever James is in Atlanta, he likes going to "Varsity" (a restaurant in downtown Atlanta).
James was one of People Magazine's Sexiest Men Alive, 2006. He is found in the "Sexy at any Height" section at 6'1".
James appeared on the Celebrity edition of the game show, Jeopardy!
James was the host of ABC and ESPN2's Primal Quest, a 10-day adventure race across the Utah desert. The show began airing on October 9, 2006.
During the 2006 break from Desperate Housewives, James went to Santa Fe in New Mexico, where he starred in a historical comedy-western called Wanted: Undead Or Alive.
James spoke at his nephew's eighth-grade graduation at Poplar Grove School in Nashville on June 12, 2006.
James starred in the play, In Walked Monk while also starring on The Pretender. For one whole month, twice a week, he played two completely different roles within a twenty-four hour period.
James auditioned for the part in The Pretender on his way home from the LAX airport.
James moved to Chicago to further pursue acting. His first role there was as Stanley in A Streetcar Named Desire.
James was married to Jenna Lyn Ward from 1997 to 2000.
James won the 2005 Screen Actors Guild Award for Outstanding Performance by an Ensemble in a Comedy Series for Desperate Housewives.
James is involved with and contributes to several charities. These include Actors and Others for Animals, The Cystic Fibrosis Foundation, and the Nashville Ronald McDonald House. He has also spoken out for Cure Autism Now and the Susan G Komen Breast Cancer Foundations.
In the past, James has been a Big Brother/mentor.
James starred in The Diviners, as a Kentucky preacher named C.C. Showers. This role gained him a nomination for a Best Actor Joseph Jefferson Award. This is Chicago's only theater award.
James' first role was as George Gibbs in a production of Our Town during the bicentennial in Nashville.
James guest starred on Reba as Dr. Morgan. He has said that he would love to return and do another episode when his schedule permitted him to.
James' father was a dentist.
James hosted the 2005 Miss America Contest, which aired on CMT.
James is often called Jamie.
James grew up in Atlanta, Georgia.
On February 19 of 2005, James was the recipient of Oprah Winfrey's Your Wildest Dream. He was taken to City of Palms, Florida to spend an afternoon training with the Boston Red Sox baseball team at their spring training facility.
On his left bicep, James has a tattoo of his late father's initials, birth and death dates, and rank and serial number in the Navy.
James dated country music star Deana Carter in high school.
James resides in Southern California with his wife, Erin, and their son and daughter.
James attended Goodlettsville High School in Tennessee.
James graduated from the University of Tennessee at Knoxville. He majored in television/ journalism and earned a degree in advertising.
James and his wife, Erin, welcomed their first child, Sheppard, on March of 2003. They welcomed their second child, a girl, on March 22, 2005. Her name was Malin O'Brien Denton, and she weighed 7 pounds, 5 ounces.
James: As an actor, when you get a script called Desperate Housewives and they ask you if you want to take it, you start thumbing through to see if you're playing a single guy, because you know he's going to get lucky!
James: (on stardom) It slows down grocery shopping because so many women at the store watch the show! I always end up talking to two or three people every time I go to the supermarket. It's fun!
James: (on filming a love scene with Teri Hatcher) She was virtually nude except for a little bit of tape here and there. But Teri is such a sweetheart and was a great sport about having to strip in front of the entire crew!
James: (on his big break in the stage production of "A Streetcar Named Desire") I had no idea what I was doing and I'm so glad that I didn't because I would have been terrified! They hired me to play in this big, 200-seat theatre in Chicago and I was so out of my league.
James (his message to Angelina Jolie after she lost her mother to cancer): My mom died of breast cancer a couple years ago, she's not alone, most of us go through it at one time or another.
James: I bought land in Montana and in a perfect world, Desperate Housewives would run for four years and then you'd never see me again.
James (At his nephews graduation): My only words are to find something you love to do and chase it and enjoy it. Do what you love to do and believe in yourself. Maybe you can wear jeans for a living and make out with Teri Hatcher.