From March 2004 until July 2006, Janeane co-hosted The Majority Report radio show with Sam Seder on Air America Radio. She would sign-off with the word "PEACHES!"
Janeane's father in real life is named Carmine. This is also the name of the skull in her bowling ball in the film Mystery Men. The skull in the film is her father, who helps her fight evil.
Janeane was the first choice to play the role of Monica on Friends but she turned it down. Janeane also turned down the part of Gail Weathers in the movie Scream. Both of these roles would later go to actress Courteney Cox.
Janeane received two Emmy nominations for her work on The Larry Sanders Show.
Janeane married her then boyfriend writer Robert Cohen at a Las Vegas drive-in chapel in 1991 as joke. After their relationship ended they never divorced.
Janeane wrote a book entitled Feel This Book: An Essential Guide to Self-Empowerment, Spiritual Supremacy, and Sexual Satisfaction with Ben Stiller.
Janeane worked briefly as a bike messenger while struggling in the beginning of her career.
Janeane was selected as #99 on Comedy Central's list of the 100 greatest stand-ups of all time.
Janeane studied history while attending Providence College.
In 1982 Janeane graduated from James E. Taylor High School in Katy, Texas.
Janeane is 5'1" tall.
Janeane is a vegetarian.
Janeane attended Madison High School in Madison, New Jersey.
Janeane is of Italian and Irish descent.
Janeane has 15 tattoos.
Janeane has a production company called I Hate Myself Productions.
Janeane: The world would be better off with multiple superpowers. When Communist USSR was a superpower, the world was better off.
Janeane: To me, there is no greater act of courage than being the one who kisses first.
Janeane: The term celebrity makes my skin crawl.
Janeane: I actually was class clown, but I don't know how that happened because I've never been considered an outwardly funny person.
Janeane: (After 9/11) Who would have thought that I'd be angry on behalf of my country? I'm used to being angry at my country.
Janeane: I guess I just prefer to see the dark side of things. The glass is always half-empty. And cracked. And I just cut my lip on it. And chipped a tooth.