From March 2004 until July 2006, Janeane co-hosted The Majority Report radio show with Sam Seder on Air America Radio. She would sign-off with the word "PEACHES!"
Janeane's father in real life is named Carmine. This is also the name of the skull in her bowling ball in the film Mystery Men. The skull in the film is her father, who helps her fight evil.
Janeane was the first choice to play the role of Monica on Friends but she turned it down. Janeane also turned down the part of Gail Weathers in the movie Scream. Both of these roles would later go to actress Courteney Cox.
Janeane married her then boyfriend writer Robert Cohen at a Las Vegas drive-in chapel in 1991 as joke. After their relationship ended they never divorced.
Janeane: I guess I just prefer to see the dark side of things. The glass is always half-empty. And cracked. And I just cut my lip on it. And chipped a tooth.