Bailey asks Richard to join her on the case of a lifetime. Meredith decides to hire a research assistant. Callie shocks Derek. A young pregnant woman needs Shane's help.
Arizona's bad day escalates when she advises a patient on a potential double amputation. Derek breaks a promise. Stephanie and Jo find an abandoned baby. The non-fraternization rule leads to a suspension.
On the day of April's wedding, the Grey Sloan Memorial doctors are all preoccupied with their own drama. Meredith and Cristina continue to argue about their research and careers, Bailey comes clean to Ben about her feelings regarding him moving back to Seattle, and Shane puts himself in a risky situation. Meanwhile, Derek gets a phone call that will change his life.moreless
The CBI work a 25 year old case which is connected to Visualize and Red John. Lisbon also thinks about her future after the arrest of Tommy Volker.
Will catches the eye of network executives and Atlantis World Media CEO Leona Lansing when he apologies on-air for his dishonest and inaccurate coverage before the November 2010 midterm elections.
Brenda's next case has her and the team investigating the brutal murder of an actress who was dating through an online service. Unfortunately the case takes a back seat when Brenda, under the guidance of Captain Raydor, must prepare for her interview with the mayor for the Chief of Police position. While Brenda still has second thoughts about whether she'd like the job, she manages to juggle the preparation with keeping a hand in the case, which was handed over to Commander Taylor.moreless