Lily and Stevie's affair becomes dangerous for them both and Judi finds herself in Klein's hands. Meanwhile, Mercedes and her father receive bad news.
Things are going badly for Ike: Meg turns down his offer, he is caught lying to Ben and Klein shows him damning evidence. Meanwhile, Stevie's affair comes back to haunt him.
Ben and Ike bet heavily on a boxing match and Vera receives another cancellation from Jackie Kennedy. Meanwhile, Danny receives photos intended for Stevie and the DA makes an important discovery.
Ike and Stevie try to persuade Judi to get out of town and Vera is desperate to get pregnant. Meanwhile, Ike's plan to sell 49% of the hotel to Meg hits a snag.moreless
The hotel thief makes another visit and Vera pursues her aim of ensuring Jackie Kennedy attends her charity function. Meanwhile, with the situation in Cuba not getting any better, Victor looks for other ways of returning his wife safely to Miami.moreless
Ike contacts his wealthy ex-sister-in-law for a favor, while trying to bribe officials to legalize casino gambling. Meanwhile, Ben wonders if his wife is being unfaithful and Vera receives a visit from an old friend.moreless
Stevie continues his affair with mobster Ben Diamond's wife, Lily, while law-student, Danny, is being used by the District Attorney to attack organized crime. Unaware of the trouble his sons could cause him, Ike tries to deal with the disappearance of Mike Strauss.moreless
Frank Sinatra is due to give a concert at the Miramar Hotel on New Year's Eve, 1958 and Ike needs it to be a big success. However, union campaigners are putting everything at risk, so in desperation he makes a deal with mobster, Ben Diamond.moreless
The town of Milan, Ohio, is plagued by a series of calls where the victims are contacted by dead loved ones, and urged to commit suicide. When Dean and Sam investigate, Dean gets a call of his own and the two brothers are soon at odds.moreless
Denny needs a heart or else. Izzie and George go crazy trying to get him one. Derek has the life of a friend in his hands as he operates on Burke who has been shot. Burke cannot operate on Denny after Denny's heart stopped and now Denny is in a dire condition. Cristina gets put in charge of the ER and she is worried about Burke.
Part 2 of a three-hour season finale. This episode is the first hour of a two-hour episode which is two hours long and will air on a Monday in a different time slot than it would on Sunday. Aired on Monday, May 15, 2006 from 9 PM EST to 10 PM EST.