Peter decides to adopt a falcon. Meanwhile, Lois receives a job as a voiceover artist, but not for the work she originally believes.
Grampa escapes from his retirement home, and when Homer and Marge frantically try to track him down, they follow clues that reveal secrets in Grampa's past. They find that he worked at a local restaurant with Marvin Hamlish and met and fell in love with the restaurant's singer Rita LaFleur. Meanwhile Lisa tries her hand at online poker, getting tips from the experts, including Jennifer Tilly but is soon gambling with her college fund.moreless
When Brian discovers that Carter Pewterschmidt's pharmaceutical company is withholding the cure for cancer from the public in order to gain more profit, he and Stewie plot to expose the big secret that could change the world. Meanwhile, Quagmire reveals a hair-raising secret of his own.moreless
The dolls may not get along, but they'll need to keep their enemies close when they're paired up for this week's challenge to not only perform together, but to do so while singing live!moreless
Phi Phi unleashes her anger onto Willam. Sharon, thinking she's about to be sent home, says a tearful goodbye to the queens. Pamela Anderson stops by to lighten the mood.
Lois cooks a big Thanksgiving meal and invites the whole crew over for dinner, and Joe is shocked when his formerly M.I.A. son, Kevin Swanson, returns from Iraq.
Lois competes in a boxing match. Peter is Lois' manager.