I came to know of Jensen through Supernatural, as probably most of us have. I can't say that I've talked to him myself, and I've never met him (the closest I came was seeing him at a convention), but my impression of him is that he is a genuine, humble, generous, hard-working, and classy guy. The list could go on! He's also a very, very talented actor.
I really respect him, as a person and as an actor, and he deserves a lot of success in the years to come.