Jesse plays the violin as part of the Band from TV, alongside several TV stars including Greg Grunberg, James Denton and fellow House star, Hugh Laurie.
He was roommates with actor James McAvoy while he lived in London.
Jesse still plays the violin, guitar and the piano.
Jesse and his House co-star Jennifer Morrison called off their engagement on August 15, 2007. They had been engaged since January 2006 when Jesse proposed at the Eiffel Tower in Paris.
He was born at St Georges Hospital in Kew, Melbourne.
Jesse was chosen as one of People Magazine's annual 100 Most Beautiful People in the World, in May 2007.
Since Jesse's father and brothers are all doctors, when they watch House, they always try to diagnose the medical problem in the show and look for medical slip-ups in the dialogue.
Jesse has blue/green eyes
Jesse appeared in the 2001 film Winning London with Mary-Kate and Ashley Olsen. He played the character Lord James Browning Jr. and had to put on an English accent for the role
In 2002, Jesse played the role of Fritz Robinson in the TV movie, Stranded. Stranded was a movie version of the book, The Swiss Family Robinson.
Jesse is listed as one of "T.V's Sexiest Men" for for 2006.
Just like his characters Billy Kennedy (Neighbours) and Robert Chase (House M.D) his real life father is a doctor.
Jesse is soon returning to Australia to make a cameo performance on Neighbours as Billy Kennedy. He previously returned for a guest spot on the show's 20th anniversary episode in 2005.
Jesse would like to see his character Chase do a one liner.
Jesse will be joining his House co-star Jennifer Morrison in the independent movie Flourish.
He was nominated for the 1999 Silver Logie in the "Most Popular Actor" category.
Jesse's favourite band is Presidents of the United States of America.
He was offered a place to study medicine at Melbourne University but he deferred it to pursue a career in acting.
Jesse's favorite food is chicken.
His favorite TV show is The X-Files.
He can speak French.
He used to have his belly button pierced with a garnet.
His hobbies include Australian football, running, rock climbing, surfing, and music.
His first role was as the understudy for the role of Louis in "The King and I."
He is the son of Rodney and Robyn Spencer.
He is 5' 10½" (1.79 m) tall.
His father and all his siblings are doctors.
He was in "Uptown Girls" with Brittany Murphy and Dakota Fanning.
He was in "Death In Holy Orders" and had to use a British accent.
He plays the guitar, the piano, the violin, and the drums.
Jesse has played the violin since the age of 10.
Jesse was in the Australian boys choir.
Jesse has two older brothers and a younger sister.
Jesse is Australian but in certain movies puts on a English accent.
Jesse Spencer: (on Jennifer Morrison) Jennifer boosted my confidence and made me more like the person I want to be.
Jesse Spencer: Mum decided that I could sing a bit, so she put me in a choir, which I hated and it was just a nightmare. I was a rebellious sort of choirboy.
Jesse Spencer: I'm from Melbourne - it's a city of about 3 million - but when you're growing up in a place like that and you think it's quite a big city, and then you travel around and you go, 'Actually... no.' So when I go back now, Melbourne feels like a country town. My mum will be in like 15 cars of traffic and she'll be complaining. And I'm like, 'That's not traffic, I'm sorry!'
Jesse Spencer: I'm the black sheep of the family.
Jesse Spencer: I'm glad I'm back to being a nobody.
Jesse Spencer: I started off with violin, then I started learning guitar, then I went to piano. But I self-taught piano just because I enjoyed it. I've always really enjoyed music. I haven't played much the last 4 years because I've been traveling around, so when I got his role [Neal in Uptown Girls], I had to start playing the guitar again.
Jesse Spencer: I always find music guys writing about love. Think of something else for a change. I'm sorry, but it's been done, and it does work and it's good and all that, but I think something else would be nice. I tend not to write lyrics, cause I'm a bad lyricist. I sort of write the music, and I can orchestrate the whole thing, but the words, [singing] 'I woke up this morning...' Awful stuff.
Jesse Spencer: Like Billy [his character in Neighbours], my dad is a GP and my two eldest brothers are too. If I wasn't acting I would have definitely gone into medicine, too. It's totally fascinating.
Jesse Spencer: It's tough in this industry - it doesn't matter whether one is auditioning for an advertisement or for a role in theatre or television - you just learn to take the hundreds of knockbacks! All these people are looking for a certain "look" for each job - the right age, height, hair type, size etc before they even consider any abilities - you learn not to get optimistic or disappointed!
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