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Jesse plays the violin as part of the Band from TV, alongside several TV stars including Greg Grunberg, James Denton and fellow House star, Hugh Laurie.
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He was roommates with actor James McAvoy while he lived in London.
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Jesse still plays the violin, guitar and the piano.
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Jesse and his House co-star Jennifer Morrison called off their engagement on August 15, 2007. They had been engaged since January 2006 when Jesse proposed at the Eiffel Tower in Paris.
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He was born at St Georges Hospital in Kew, Melbourne.
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Jesse was chosen as one of People Magazine's annual 100 Most Beautiful People in the World, in May 2007.
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Since Jesse's father and brothers are all doctors, when they watch House, they always try to diagnose the medical problem in the show and look for medical slip-ups in the dialogue.
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Jesse has blue/green eyes
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Jesse appeared in the 2001 film Winning London with Mary-Kate and Ashley Olsen. He played the character Lord James Browning Jr. and had to put on an English accent for the role
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In 2002, Jesse played the role of Fritz Robinson in the TV movie, Stranded. Stranded was a movie version of the book, The Swiss Family Robinson.
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Jesse is listed as one of "T.V's Sexiest Men" for for 2006.
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Just like his characters Billy Kennedy (Neighbours) and Robert Chase (House M.D) his real life father is a doctor.
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Jesse is soon returning to Australia to make a cameo performance on Neighbours as Billy Kennedy. He previously returned for a guest spot on the show's 20th anniversary episode in 2005.
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Jesse would like to see his character Chase do a one liner.
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Jesse will be joining his House co-star Jennifer Morrison in the independent movie Flourish.
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He was nominated for the 1999 Silver Logie in the "Most Popular Actor" category.
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Jesse's favourite band is Presidents of the United States of America.
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He was offered a place to study medicine at Melbourne University but he deferred it to pursue a career in acting.
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Jesse's favorite food is chicken.
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His favorite TV show is The X-Files.
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He can speak French.
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He used to have his belly button pierced with a garnet.
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His hobbies include Australian football, running, rock climbing, surfing, and music.
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His first role was as the understudy for the role of Louis in "The King and I."
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He is the son of Rodney and Robyn Spencer.
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He is 5' 10½" (1.79 m) tall.
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His father and all his siblings are doctors.
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He was in "Uptown Girls" with Brittany Murphy and Dakota Fanning.
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He was in "Death In Holy Orders" and had to use a British accent.
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He plays the guitar, the piano, the violin, and the drums.
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Jesse has played the violin since the age of 10.
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Jesse was in the Australian boys choir.
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Jesse has two older brothers and a younger sister.
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Jesse is Australian but in certain movies puts on a English accent.