John was nominated for a Best Supporting Actor Oscar in 2002 for Chicago.
John has been nominated for three Golden Globe awards. In 2003 he was nominated for Best Performance by an Actor in a Supporting Role in a Motion Picture for Chicago. In 2008 he was nominated for both Best Original Song - Motion Picture and Best Performance by an Actor in a Motion Picture - Musical or Comedy for Walk Hard: The Dewey Cox Story.
John has been nominated for 5 SAG awards, all in the category of Outstanding Performance by a Cast in a Theatrical Motion Picture. In 1998, John was nominated for the movie Boogie Nights. In 2000 the movie was Magnolia. In 2003 he was nominated for both The Hours and Chicago. He won for i>Chicago. In 2005 he was nominated for The Aviator.
Originated the role of Marty in the 2002 musical "Marty" (book by Rupert Holmes, music by Charles Strouse, lyrics by Lee Adams), based on the 1955 movie Marty (1955).
He received a Bachelor of Fine Arts degree from DePaul University's Goodman School of Drama (Chicago) 
In April 2004 he left the filming of Manderlay (2005) to be replaced by Slovenian actor Zeljko Ivanek. According to a report in Entertainment Weekly, he did so to protest against the killing of a donkey during production.
John is a wonderful singer who came out of a musical theater background - did all of his own singing in Chicago (2002).
In 2003, he starred in three out of the five movies nominated for Best Pictures. They are Chicago (2002), Gangs of New York (2002), and The Hours (2002).
He made a home video of himself singing in a bow tie and suit for director Rob Marshall who gave him his role in Chicago (2002).
His mother is from Lithuania. Father is Irish. He is the fifth of six children.
The director Antoine Fuqua wanted to cast him in his since aborted crime epic "Tru Blu" with Denzel Washington and Benicio Del Toro.
For not only his broad, 6' 2" frame, curly hair, and everyman's mug, but also his straight-forward but thoughtful acting style, Reilly has frequently been dubbed "his generation's Gene Hackman".
He was nominated for Broadway's 2000 Tony Award as Best Actor (Play) for a revival of Sam Shepard's "True West."
He graduated from Brother Rice High School on the South Side of Chicago.
John C. Reilly: Like most baked goods, soda bread doesn't keep for long. If properly cooled, wrapped well in plastic, and stored at room temperature, it will maintain its quality for about two days.
John C. Reilly: One of the unique things is that whether we were out at sea or in the middle of the water tank, a lot of times you just couldn't leave. Especially when we were out at sea.
John C. Reilly: My dad was a big fisherman. He passed away, but a lot of time I spent growing up was on the water, so a lot of my best memories are from that.
John C. Reilly: In Magnolia, I had to learn all this police training. In For Love of the Game, I had to perform like a major-league baseball player.
John C. Reilly: I try to take things that challenge me either physically or mentally, or I have to learn a new skill.
John C. Reilly: In Chicago it's really a case of the play's the thing - people are just so happy to be acting, you know? We were all actors - not like in New York or Los Angeles, where everyone says they are actors but they are actually waiting tables and hustling for spots in commercials. We might not have been paid very much, but we were doing what we wanted to do and I got a lot of experience that way, a lot of versatility, so I was ready when a big chance came along.
John C. Reilly: I was a bit of a freak, but because I had a few older brothers I was afforded protection and people just kind of let me join their gangs. I was a kind of Zelig figure, moving between different groups. I'd hang with the jocks, the burn-outs, the academic types and I could empathise with all of them. I was curious about all of them, but I know I never felt I fitted in with them, you know? It sounds odd saying it now, but I just wasn't right there - until I started doing plays and then it was, like: "Ah, my people."
John C. Reilly: Not because I find fame difficult, but because I fear that if you're too well known, you lose the ability to surprise your audience and that's what I like my characters to do. I can still get away with it, I think. I mean, those kids in the lobby didn't know my name and I did an interview yesterday where they looked very confused when I walked in. Turns out they were expecting Philip Seymour Hoffman, though they didn't really know his name either - they just sort of said to me: 'Have you lost weight and dyed your hair?'
John C. Reilly: The C stands for Christopher. You can blame the union for that. The Screen Actors Guild make you do it if there's another member with the same name. I wasn't going to change my name, so I just included the middle one. It was a decision I had to make on Casualties of War (1989), my first film in 1989. I got a phone call and had to fly out to Thailand where Brian De Palma was shooting and it was a sudden decision, and I'm stuck with it. So I'm glad I didn't go for a stupid and exotic-sounding name just to grab attention, or you could be talking to a man named Tallulah or something.
John C. Reilly: I think there's something about me...that people can relate to. And, you know, beauty can be its own prison. (On his reputation as "character actor" rather than leading man)