Mitch and Jamie try to disrupt Davies' plans and are helped by two unexpected allies. Meanwhile, Jackson and the others meet with Robert's sponsors in Pangaea and try to develop a cure.
Jackson, Jamie, and Mitch return to the bunker to recover the stolen serum after the Shepherds' betrayal... but one of them won't be coming back out.
While Mitch and Jamie work together when animals attack the Russian embassy, Robert provides an explanation to Jackson as Davies' people close in on the jet.
While Mitch and Abe try to find Jackson, Allison and Jamie meet with the Russian Minister of Defense and try to convince him to withdraw his country from the Noah Objective.
Mitch and Allison contact Mitch's father Max, a cryptozoologist who can help them date the last set of bones. Meanwhile, Abe faces a difficult decision after Elizabeth mutates and attacks Jackson.
Jackson learns that his mother Ellizabeth has gone missing and demands that Allison sends a rescue team. Before she can, Davies leads an assault on the plane to capture Jackson.
While Mitch and Jackson try to recover a clue to the cure from Jackson's memories, the others head to New England to follow a new lead.
After reuniting with Jamie, the team travels to Portugal to obtain some jellyfish venom in search of a cure for the animal mutation. Meanwhile, Jackson's mutation begins to endanger his teammates.
Jamie and Logan finally reach Caraquet but discover that it's not what they expected.
The team has to infiltrate a Reiden black-tie party to recover a sloth with the new mutation, and discover what Davies' plan is to wipe out the mutated animals. Meanwhile, Jamie continues her trek to civilization.moreless
The team heads to New Brunswick to rescue Jamie and the leopard cub that holds the potential cure to the mutation. Meanwhile, the mutation spreads to insects and hundreds are killed in DC.moreless
The team travels to Argentina to make contact with a fellow researcher and find an amazing discovery. Meanwhile, Jamie tries to make her way to civilization and meets a stranger on the road.moreless
In Zambia, the team try to find a leopard so that they can create the cure. Meanwhile, Chloe is tortured for the team's location.
As Jackson undergoes surgery, Mitch and Jamie try to create a cure to the mutation using the Mother Cell and the leopard DNA.
To get to Zambia to gather leopard DNA and cure the outbreak, the team turns to an animal rights activist to escape the U.S. ahead of the authorities.
Once Mitch tells them that Delavane is working for Reiden, the team try to get their story out via Jamie's friend in the press. Meanwhile, Jackson and Chloe pay Delavane a visit, and Mitch and Abraham deliver the stolen medication to Clementine.moreless
The team goes to an American tourist island in Massachusetts to investigate an outbreak of rats that have already killed the crew of a cargo ship. Meanwhile, Mitch pays Clementine a visit and then prepares to trade the Mother Cell for his daughter's cure.moreless
The team investigate a bear attack in France, and Chloe reunited with her ex-fiancé. Meanwhile, Mitch discovers the next evolutionary step of the mutated animals, while the team prepares to hack Reiden's mainframe after Jamie is accused of Ben's murder.moreless
In Rio, Abraham tries to track down his friends, who are stalling for time with Gustavo. Meanwhile, Jackson and Ben find Jamie after the crash, and set out to find Evan Lee. In France, a woman is subject to a bizarre home invasion.moreless
While Mitch, Chloe, and Abraham travel to Rio de Janeiro to stop the government's bat extermination program, Jackson, Jamie, and Ben try to find a chemist who can connect Reiden to the animal attacks.moreless
The team travels to Mississippi and investigates the wolf attack on the prison. Mitch and Abraham try to capture a wolf, while Chloe, Jackson, and Jamie search the prison and meet FBI agent Ben Shaffer.moreless
While Jackson and Abraham travel to a remote island to find Robert's research, Jamie convinces Mitch to go to New Orleans with her to present the case against Reiden. Meanwhile, wolves launch an attack on a prison, and Gaspald shows Jamie the crime scene in Slovenia.moreless
Jackson rescues Abraham and talks with the local doctor--his mother Elizabeth--who confirms that the lions killed their victims as slowly and painfully as possible. In Slovenia, a British couple adopt a young boy and take him to the circus to see the tigers. And in Paris, Chloe meets with a mysterious man who offers her answers.moreless
Two fatal lion attacks, thousands of miles distant, are the first indications of a threat that could wipe out all humanity.