Hank treats Cinco while Evan and Paige work with Emma to set a trap for Oz. Divya and Jeremiah have a bitter boat-builder as a patient. Hank assists Charlotte.
On the day of April's wedding, the Grey Sloan Memorial doctors are all preoccupied with their own drama. Meredith and Cristina continue to argue about their research and careers, Bailey comes clean to Ben about her feelings regarding him moving back to Seattle, and Shane puts himself in a risky situation. Meanwhile, Derek gets a phone call that will change his life.moreless
April’s sisters arrive to help celebrate April’s upcoming nuptials and quickly get on her nerves. Matthew and Jackson are forced to work together when they witness a terrible accident, Callie and Arizona work hard to reestablish their relationship and Cristina is pressured to live stream an upcoming surgery. Meanwhile, a familiar face returns to the hospital.moreless
With everything going on in Ravenswood, Caleb discovers that it is way too hard to talk Hanna about the recent events happening. With the help of Remy, Caleb meets a long-ago relative who ends up making sense of things for him but brings more questions. Luke, finding it difficult with going along with Caleb, Olivia, and Remy and their theories, decides to seek a diversion from it all. Olivia and Miranda figure out a link between their families with the new information found.moreless
The issues between Meredith and Cristina hit a boiling point when one of them ultimately betrays the other at the hospital. Derek tells Jackson that he needs to let go and allow the second year doctors to work on his patients, and April and Matthew make a bold decision about their relationship. Meanwhile, Bailey has difficulties with Ben’s return.moreless
Catherine's surveillance job turns deadly. In order to save Kono, Adam reflects on what his best move should be.
Five strangers come together to try and stop a town's curse.
A runaway bride is the main suspect when a wedding crasher is murdered. Danny decides where his relationship with Gabby is headed.
To solve a double murder, Five-0 gets some help from a conspiracy theorist.
Five-0 assists a Texas Ranger in finding his missing daughter when they cross paths with him during a murder investigation. Adam and Kono run into problems and find themselves fighting for their lives.moreless
The fight continues to save those affected by the storm, Callie makes a bold decision regarding her relationship, and the doctors come together upon receiving devastating news.
Bay arranges a Deaf Day at Maui, Kansas and asks Emmett for help with a screening of the movie "Deafenstein". John asks Regina to redecorate his office at the car wash. Ty accuses of Bay of playing him in order to make Emmett jealous. Kathryn goes to see Bill asking for him to smooth things before it's too late. Regina encourages Toby to tell Nikki the truth about who her father was. Bay discovers that Ty is being deployed back to Afghanistan. Daphne begins to wonder what kind of a person Jace really is after he destroys Jeff's relationship with his fianceé.
Five-0 is assigned by the CIA to find a missing federal prisoner after the plane he is being transported to Oahu on arrives without him, but instead has four dead bodies. After being set up for a murder, Kono finds herself on the outs again with the police force. Steve has another surprising encounter with Wo Fat. Danny reconnects with Gabrielle.moreless
The storm rages the Grey Sloan Memorial Hospital and resources become scarce. One doctor goes to labor, another doctor's affair found out and an engaged doctor have second thoughts about marriage.
The doctors of Grey Sloan Memorial Hospital prepare for a super storm heading towards Seattle; Owen's desire to be a parent gets stronger as he becomes closer to Ethan; and one wrong move puts the lives of Meredith and her baby in jeopardy. Meanwhile, Jo looks to Alex for help in a moment of crisis, and one doctor gets the shock of her life.moreless
Bailey finds herself at the center of a CDC investigation surrounding the death of several of her patients, as Jackson and the rest of the board members argue over how to address the crisis with the public. Meanwhile, Cristina teases Alex about his unspoken feelings for Jo, and Owen continues to take special care of Ethan as the condition of his parents remains uncertain.moreless
Upon receiving some unsettling news, Meredith and Derek take preventative steps for their children's future; a group of Syrian doctors arrive at Grey Sloan Memorial Hospital for a crash course in basic surgical skills that they plan to apply in the field; and April decides to come clean to Matthew regarding the truth about her virginity. Meanwhile, multiple pre-op patients develop infections, causing one doctor to wonder if she is at fault.moreless
A gas tanker explodes on a Seattle highway, causing multiple injuries -- including paramedic Matthew; Meredith and Jo help a frantic mother (Sarah Chalke) whose child is suffering from a mysterious illness; and Owen bonds with a young boy whose parents are in critical condition. Meanwhile true colors are revealed when Alex is forced to work with Jo's boyfriend on an ailing patient.moreless
Callie comes up with an idea to save the hospital while Owen addresses the plan to sell to Pegasus to the doctors and nurses. April's date surprises her with a secret of his own.moreless
Competition heats up as several of the doctors fight to become the new face of Seattle Grace; April brings in an emergency case, and Jackson and Alex work with a transgender teen couple. Meanwhile, the hospital implements new policies which test the patience of the staff.moreless
The Seattle Grace doctors are on edge when a new medical professional enters the hospital; Arizona struggles with the emotional and physical pain of a phantom limb; and while battling pregnancy hormones, an overly-emotional Meredith is confronted with her worst fear.moreless
John and Kathryn consider running for public office. Bay is accused of cheating. Angelo starts spending his money on gifts.
The Kennish's head to Court. Meanwhile, Daphne is in trouble because of her relationship with Jeff.
The lawsuit against the hospital comes to a head as Angelo returns in time for the beginning of the trial. Meanwhile, Bay scrambles to return the money she "borrowed" from John to help Zarra.moreless
Bay is called upon to rescue Zarra from a sticky situation; Scuba asks Daphne to lie to Chef Jeff; Toby and Nikki bond.
Bay and Zarra get into a dangerous situation when they search for the tagger who is ruining their street art; Chef Jeff's mixed signals confuse Daphne.
Daphne's Boss is well like by Kathryn, Melody, and Regina. Bay uses Angelo to get around Johns rules.
Regina's impulsive wedding creates major consequences for the Vasquez and Kennish families; John's baseball record may be broken; Daphne and Emmett enter their zombie flick in a film festival, andBay considers being part of a street art crew.moreless
Daphne is on the job hunt and finally gets one at a restaurant called Maize, where she befriends a line cook named Scuba.