Rachel agrees to decipher the secret code in Ethan's book but Sarah and the clone club will have to find a secret way out of Dyad for Rachel. Helena and Gracie work with Alison and Donnie at Bubbles. Donnie confronts Allison about Jason’s kiss and devises a plan to set Jason straight. Dr. Coady and Benchman scheme to track down the Castor Original. Rudy drops in on DYAD for a much needed asset. A new clone enters the picture.moreless
Alison must secure a store front in order to take their drug business to the “next level”. But Allison's her mother, Connie, proves to be a major hindrance. Felix helps Allison on her campaign for school trustee. Cosima, facing familiar health issues she thought she was over, calls on Alison for a favor. But it's Cosima who ends up doing a favor what with Alison trying to save Donnie from a heartless drug lord. Unassuming Scott gets closer to the greatest discovery of all when he sits down with Rachel to work on the secret key to decipher Ethan’s book, The Island of Dr Moreau.moreless
Paul finds the ugly truth behind the Castor Boys’ logbooks of names which pushes him into action. Felix is desperate for information on Sarah’s whereabouts so he pressures the still-ailing Rachel for any shred of a lead. In order for Donnie and Alison to take their money-making endeavor to the "next level" she must convince Jason Kellerman that her unique business plan will work.moreless
Sarah must step in to help when Mark is taken down in a Prolethean shoot-out. As Sarah collects intel putting her on the trail of the original Castor DNA, a familiar foe is not far behind. Helena continues to toil in a faraway military compound but it is ultimately Sarah’s fate that will hang in the balance as she tries to save her sister. Gracie is cast out from the Prolethean fold. Alison and Donnie come face-to-face with an unhappy drug lord.moreless
The family surprises Lip with a party for his high-school graduation. Frank starts bonding with Lip after learning that his alcoholism is affecting his health. Ian decides to enlist.
When questioning her future with Jimmy, Fiona takes the kids on a camping trip with her boss. Ian is heartbroken over Mickey's wedding to the girl he got pregnant. Lip is suspicious of Mandy. Meanwhile, Frank and Carl plan a heist.moreless
Just when Fiona's life seems to be a little less complicated, Jimmy reveals his desire to return to med school. Elsewhere, Frank enjoys his newfound celebrity.
Fiona starts a new job at an office. Mandy affects Lip's future, while Karen pushes Mandy to the edge. Frank manages to become the public face of a gay rights movement.
After Cousin Patrick's appearance with another Aunt Ginger will leaving her house to him, the Gallagher's try to come up with a plan to keep him from evicting them from their home. Meanwhile, Frank has to leave Sheila's home with Hymie gone, but soon finds an alternative as live-in sponsor. Kev and V's baby-making plan introduces a new problem and Sheila makes a shocking discovery about her daughter.moreless
Fiona goes to great lengths to become her siblings' custodian, but Frank doesn't want to give up his paternal rights.
After the kids are taken away by child protective services, Fiona decides tries to figure out how to get the kids back, even going as far as turning to Frank for help. Meanwhile, when having Veronica's mother be a surrogate is proven a challenge, Kev and Veronica decide it's time for desperate measures.moreless
The city of Chicago is digging up the sewer main. This is bad because Aunt Ginger is still buried in lawn and the Gallaghers have to find her before the city does.
Carl heads off to cancer camp. Lip helps Mandy find her estranged younger half-sister, whose mother just died. With Frank on babysitting duty, Sheila tries to convince Jody to mix things up in bed. Meanwhile, Jimmy learns some truth about his dad.moreless
Kev's wife returns and Veronica fears a connection. Frank's latest scheme is telling Carl he has cancer to scam a charity foundation. Meanwhile, sexual harassment arises when Fiona applies for a job as a cashier in a grocery store, and Lip leads a crusade to take down sex offenders in the neighborhood.moreless
Fiona stresses over booking a club night, while Lip stresses over the money she used to get the gig. Estefania's father recruits a hitman to follow Jimmy everywhere he goes. Meanwhile, Frank needs to find a new home.moreless
Now that Jimmy is a little more boring, Fiona has to work on adjusting to the changes. Jimmy is confronted by his past. Frank, meanwhile, wakes up in a land completely foreign to him after one serious blackout.moreless
At Stevie's bar mitzvah, friends and family gather and Nancy tries to reconnect with her estranged loved ones.
Jimmy thinks about introducing Fiona to his family, while Frank tries to bust Monica out of the psychiatric institution and Sheila and Jody try to raise Karen's child as their own.
Fiona tries to organize a Thanksgiving dinner with the little money they have left after Monica spent the Squirrel Fund. Meanwhile, Frank tries to get Monica out of her depression and Steve finally reunites Estefania with her boyfriend Marco. Elsewhere, Lip prepares a tape for his son, but the delivery holds a surprise for him.moreless
While Monica stirs things up, Fiona tries to plan her own future.
Monica shows up again and Frank tries to get his hands on the inheritance. Meanwhile, Jody and Sheila think they are haunted.
Frank discovers Ian and Mickey's relationship. Meanwhile, Jody and Sheila take care of Grammy who is dying. Lip wants to leave school and Fiona tells him about her plans to go back and get a GED.moreless
Fiona walks into Steve and his new girlfriend Estefania on Jasmine's end-of-summer blowout. In the meantime, Frank tries to get rid of Grammy, while Fiona enjoys her company. Lip prepares a prenup for Jody and Karen.moreless
Grammy Gallagher shows up to find her old meth lab pal who owes her money.
Frank believes he should get Eddie Jackson's pension when Eddie's body is discovered. In the meantime, Lip makes a discovery about Karen and Jody, Veronica doubts Kev is faithful to her and Fiona goes to a high-class wedding with her sugar daddy.moreless
Frank tries to get closer to Dottie while Fiona meets a now married high-school crush of hers, and Kev thinks about buying the Alibi.