Kathryn began her acting career in 1984 with the role of Mrs. Clark in the film Grandview U.S.A. alongside Jamie Lee Curtis and Patrick Swayze.
In one of her two appearances on The View Karen revealed to the world that she was a lung cancer survivor.
Kathryn was nominated in 2008 for a SAG Award along with her Desperate Housewives castmates for Outstanding Performance by an Ensemble in a Comedy Series.
When her mom was dying, Kathryn vowed that someday she would pursue her dreams of acting.
She began acting at the age of 45.
In 2005, Kathryn won an Emmy for Outstanding Guest Actress in a Comedy Series playing Karen McCluskey on Desperate Housewives. Kathryn won again for the same category and the same show in 2008.
She has appeared in over a dozen plays, six movies, eleven national television commercials, two pilots, ten drama series and over twenty sitcoms.
In his autobiographical novel "A Heartbreaking Work of Staggering Genius," (p.33, "Mistakes We Knew We Were Making) David Eggers reveals that Kathryn Joosten hung the wallpaper in his bedroom when he was a child.