Lisa campaigns against genetically modified organisms. Marge teaches abstinence counseling to church teens. Sideshow Bob resurfaces as a scientist.
Lisa tries to cheer up a down-in-the-dumps Homer by winning him a "MyPad" at the school auction. But he falls back into a funk when he breaks the magical tablet device – until Ned Flanders discovers a miracle tree in the Simpsons' backyard with bark that spells the word "HOPE."moreless
While Miller publishes a story that threatens to destroy Kane, he battles to stay on top, but is concerned over Doyle's alliance with Kitty.
As the city's emergency managers prepare to take over, Kane's enemies threaten to unseat him.
In order to keep his grip on Chicago, Kane finds he has no choice but to work with Alderman Ross.
Now that Kane's treatment seems to have worked, he must regain control of Chicago.
With riots breaking out at the housing project, Kane seeks treatment at an alternative clinic, but his past comes back to haunt him.
While the symptoms of his disease leave him unable to differentiate between reality and hallucinations, his hold over the City Council is threatened by his anti-corruption stance.
While his wife and daughter reject his efforts to reconnect, Kane streamlines his political staff.
Kane decides to redevelop a housing project, to get closer to Mona.
Needing to find a replacement for Stone, Kane hires an ambitious newcomer to the political scene and entices his adversary's aide.
Mayor Thomas Kane attempts to ignore the symptoms and hallucinations of his disease and concentrate on new enhancements to the terminals at Chicago airport.
The family are evicted from Springfield and join an off-the-grid community outside of town. But when Homer and Marge try to sneak back into town, they are welcomed with hostility from their former friends and neighbors and begin to appreciate their new and more accepting home in this milestone 500th episode.moreless
Tracy goes on the offensive against Liz by coming to the defense of idiots. Jack faces another challenge from Devin and meddles in Liz's relationship with Criss. Jenna and Kenneth get help from Kelsey Grammer in dealing with an unconscious Pete.moreless
An uproar ensues after cellphone video of Tracy being offensive towards gays is posted online. Liz tries to hide all details of her new boyfriend from Jack, knowing she'll never secure his approval. Kenneth and Jenna call on Kelsey Grammar for a problem only the Best Friends Gang can solve.moreless
Election day is finally here and as the candidates await the results, Kane and Stone must work behind the scenes to alter the political climate to their advantage. Meredith takes drastic steps to prove her allegiance to Kane while Emma's world comes crashing down.moreless
Kane races against the clock to repair his public image. Zajac and Meredith make their move against Kane with interesting results. Miller receives an unexpected offer.
With his political image at an all-time low, Kane takes an unexpected break from City Hall to visit an old friend. Meredith starts to question Tom's ability to weather this storm, and pursues interests of her own. Kitty makes a bold decision.moreless
After deeply buried information about his past comes to light, Kane and his staff attempt to manipulate the media by trying to control the tide of public perception.
Kane's political credibility comes into question as supporters start to lose confidence. Zajac attempts a bold move to further his campaign. Miller continues his search for answers.
Kane continues to have problems in managing his condition. Zajac's campaign starts to gain momentum. Miller discovers that his story might have more to it than meets the eye. Governor Cullen gets caught in the middle of an embarrassing media storm.moreless
With only a few weeks until the primary, the governor's race heats up as a new political force enters the scene. Kane uses his political clout to deflect stonewalling by the City Council. Meredith receives some unexpected information that makes her suspect Tom might have a secret.moreless
After being diagnosed with a degenerative neurological disorder, Chicago Mayor Tom Kane must set aside his personal issues as he attempts to run the city with an iron fist, while also dealing with the upcoming gubernatorial primary.moreless
Malik experiences depression over losing Jenna and faces the consequences of his relationship with Parker: his position on the team is in jeopardy. Meanwhile, Derwin and Melanie work on getting pregnant and Tasha meets a terminally ill man who changes her outlook on life.moreless
Malik tries to get Parker off his back and Tasha lies to everyone about her break-up with Dante.
Melanie gets a visit from her parents and Jason leaves Britt in Tasha's care.
Melanie gets jealous with all the groupies and fanmail Derwin is been getting, so she tries to spice things up in the bedroom for him. Meanwhile, Malik's happiness may be shattered a little too soon.moreless
Kelly is trying to save her show and ends up saving herself in the process and Malik's finally starting to show some improvement from rehab.
Derwin puts his relationship at risk for the sake of spending time with his son and Tasha has money/love problems with Dante.