Sheldon once again has to keep a secret when he learns Leonard and Penny are going to break up. Howard keeps getting teased by his fellow astronauts in space.
Wolowitz is caught in an argument between Bernadette and his mom, even while he's in space. Meanwhile, with his friends on dates, Raj feels lonely.
Andy encounters what could be a big bump in his relationship, while Silas moves towards some professional upward mobility. Meanwhile, Nancy joins Rabbi Dave for some dinner with friends.
Nancy looks for a job while Andy and Doug find out that one of them knocked up Jill. Meanwhile, Silas tries to get back his stolen plants.
A bachelor party and his sexual past puts Howard's marriage to Bernadette in jeopardy.
Sheldon incurs Amy's ire when he chooses a weekend of videogaming with the guys over a birthday party for her aunt.
Leonard can't take Sheldon's continued selfishness and agrees to dissolve the Roommate Agreement. Howard wants to have a cool nickname for when he's an astronaut.
Sheldon finds himself jealous when Amy goes on a date with Stuart. The other guys can't resist the allure of the latest collectable card game expansion pack.
Leonard finds himself drawn towards a comely comic book illustrator. Meanwhile, Sheldon tries to scare the gang for Halloween.
Sheldon is miffed that Leonard plans to attend a party hosted by his nemesis, Wil Wheaton. Meanwhile, Howard is offered a chance to be a payload specialist on the International Space Station.