Fiona starts a new job at an office. Mandy affects Lip's future, while Karen pushes Mandy to the edge. Frank manages to become the public face of a gay rights movement.
After Cousin Patrick's appearance with another Aunt Ginger will leaving her house to him, the Gallagher's try to come up with a plan to keep him from evicting them from their home. Meanwhile, Frank has to leave Sheila's home with Hymie gone, but soon finds an alternative as live-in sponsor. Kev and V's baby-making plan introduces a new problem and Sheila makes a shocking discovery about her daughter.moreless
Fiona goes to great lengths to become her siblings' custodian, but Frank doesn't want to give up his paternal rights.
After the kids are taken away by child protective services, Fiona decides tries to figure out how to get the kids back, even going as far as turning to Frank for help. Meanwhile, when having Veronica's mother be a surrogate is proven a challenge, Kev and Veronica decide it's time for desperate measures.moreless
The city of Chicago is digging up the sewer main. This is bad because Aunt Ginger is still buried in lawn and the Gallaghers have to find her before the city does.
Carl heads off to cancer camp. Lip helps Mandy find her estranged younger half-sister, whose mother just died. With Frank on babysitting duty, Sheila tries to convince Jody to mix things up in bed. Meanwhile, Jimmy learns some truth about his dad.moreless
Kev's wife returns and Veronica fears a connection. Frank's latest scheme is telling Carl he has cancer to scam a charity foundation. Meanwhile, sexual harassment arises when Fiona applies for a job as a cashier in a grocery store, and Lip leads a crusade to take down sex offenders in the neighborhood.moreless
With a special farewell to the doctors of Seaside Health and Wellness, Addison marries Jake with Naomi by her side, Cooper must cope with being a stay-at-home father and Violet starts a new project.moreless
Fiona stresses over booking a club night, while Lip stresses over the money she used to get the gig. Estefania's father recruits a hitman to follow Jimmy everywhere he goes. Meanwhile, Frank needs to find a new home.moreless
Addison is concerned that the judge in Henry's case still has concerns about Jake. Miranda meets Sheldon's friends. Charlotte goes into labor.
Now that Jimmy is a little more boring, Fiona has to work on adjusting to the changes. Jimmy is confronted by his past. Frank, meanwhile, wakes up in a land completely foreign to him after one serious blackout.moreless
After Amelia gets set up on a series of disastrous blind dates, she decides to go it alone for the foreseeable future. But when she teams up with James for a medical procedure and then agrees to dinner, one thing lead to another.moreless
While on doctor-ordered bed rest, Charlotte balances her pregnancy and her responsibilities at St. Ambrose Hospital but Mason is afraid she might never leave the hospital.
Sheldon discovers happiness with a new woman but is suspicious about Nick's involvement in Sarah's disappearance.
The lives of the triplets are endangered because of a fight between Cooper and Charlotte. Violet is there to comfort a friend when it comes time to take a loved one off life support.moreless
Jake finds out he'll need to meet Henry's social worker. Addison is wary about one of Jake's patients while James continues to pursue Amelia.
Addison gets a surprise when Henry's biological mother shows up and wants to be involved in his life. Addison links up again with her mentor.
The search continues for the missing girl. Sam's new career in reality television puts the light on some of his colleagues' personal lives. Sam's mother needs his help when her boss gets sick.moreless
Sheldon becomes worried when a little girl goes missing from the hospital emergency room. Jake and Addison have differing views about a patient. Saint Ambrose Hospital gets a new doctor. Sam faces questions from Stephanie about his past relationship with Addison.moreless
Violet is having trouble moving on now that Pete isn't around, but it's a patient's disturbing admission that has her turning to Sheldon. Addison does her best to hide her anguish from the others. Cooper and Charlotte become accustomed to their new daily lives while Sheldon and Sam have a face to face.moreless
A celebration and some reminiscing about the past brings everyone together at Addison's house. Sheldon has a suicidal patient with a shocking confession.
Addison makes her decision between Jake and Sam and settles into her promising romance. Pete doesn't show up for his preliminary hearing, leaving Violet to fear the worst. Charlotte receives some unsettling news. Amelia's been sober for a year now and Sheldon lights up a romance with his ex-wife.moreless
As the other doctors rush to her side, Amelia faces a hard decision when she goes into labor. Pete and Violet finally come to realize what they mean to each other. Addison has to make a decision.moreless
The residents determine their future as they make their final decisions regarding post residency positions; Mark admits to Derek that he is torn between his love for Lexie and the fact that Julia can give him everything he's ever wanted; Ben plans something extra special for Bailey, but she is preoccupied with her work; and Arizona encourages her childhood friend, Nick, to have surgery. Meanwhile a couple on their third honeymoon come to the hospital complaining of mysterious symptoms.moreless
Pete's decision about a patient has far reaching effects. Jake gives Amelia support to prevent her from misusing drugs again. Sheldon and Violet work together with a family troubled about the father's change in sexual appetite. Addison and Sam strive to figure out their situation.moreless
The residents agonize over their oral boards, reliving every answer they gave during their exams; Arizona's close childhood friend comes to Seattle Grace for medical help; the doctors work on a patient who is missing one third of his skull; and Julia asks Mark to start a family with her. Meanwhile Catherine tells Richard that one of his residents has failed.moreless
The team treats an illegal immigrant who self-induces her pregnancy which will allow her child be to be a U.S. citizen. Violet and Cooper help a young girl and her parents deal with her gender identity disorder. Before they start dating, Violet wants to continue therapy with Pete. Cooper continues with Mason's abrupt attitude towards him.moreless
Violet and Pete decide to give counseling a try. Amelia receives some news that causes her to retreat from her colleagues. Addison fine tunes her life to let in a new man. Mason gives Charlotte and Cooper cause for worry. A relative of one of her patients makes Violet suspicious.moreless
Cooper and Charlotte try to prepare Mason for the inevitable when Erica's medical condition quickly deteriorates. Violet and Pete discover they still have feelings for each other. Addison urges Amelia to welcome her pregnancy. Sheldon and Jake work with a pregnant woman who is in jail for killing two of her children.moreless
When Sam insists Corinne be released from the hospital to his care at home, Sheldon warns him he's in over his head. Pete treats Scott when he shows up in the ER badly beaten. Amelia has to decide what to do with her pregnancy. While visiting his daughter at college, Jake gets the third degree about his love life. Erica's health takes a down turn.moreless