With a special farewell to the doctors of Seaside Health and Wellness, Addison marries Jake with Naomi by her side, Cooper must cope with being a stay-at-home father and Violet starts a new project.
morelessAddison is concerned that the judge in Henry's case still has concerns about Jake. Miranda meets Sheldon's friends. Charlotte goes into labor.
After Amelia gets set up on a series of disastrous blind dates, she decides to go it alone for the foreseeable future. But when she teams up with James for a medical procedure and then agrees to dinner, one thing lead to another.
morelessWhile on doctor-ordered bed rest, Charlotte balances her pregnancy and her responsibilities at St. Ambrose Hospital but Mason is afraid she might never leave the hospital.
Sheldon discovers happiness with a new woman but is suspicious about Nick's involvement in Sarah's disappearance.
The lives of the triplets are endangered because of a fight between Cooper and Charlotte. Violet is there to comfort a friend when it comes time to take a loved one off life support.
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Jake finds out he'll need to meet Henry's social worker. Addison is wary about one of Jake's patients while James continues to pursue Amelia.
Addison gets a surprise when Henry's biological mother shows up and wants to be involved in his life. Addison links up again with her mentor.
The search continues for the missing girl. Sam's new career in reality television puts the light on some of his colleagues' personal lives. Sam's mother needs his help when her boss gets sick.
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Sheldon becomes worried when a little girl goes missing from the hospital emergency room. Jake and Addison have differing views about a patient. Saint Ambrose Hospital gets a new doctor. Sam faces questions from Stephanie about his past relationship with Addison.
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Violet is having trouble moving on now that Pete isn't around, but it's a patient's disturbing admission that has her turning to Sheldon. Addison does her best to hide her anguish from the others. Cooper and Charlotte become accustomed to their new daily lives while Sheldon and Sam have a face to face.
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A celebration and some reminiscing about the past brings everyone together at Addison's house. Sheldon has a suicidal patient with a shocking confession.
Addison makes her decision between Jake and Sam and settles into her promising romance. Pete doesn't show up for his preliminary hearing, leaving Violet to fear the worst. Charlotte receives some unsettling news. Amelia's been sober for a year now and Sheldon lights up a romance with his ex-wife.
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As the other doctors rush to her side, Amelia faces a hard decision when she goes into labor. Pete and Violet finally come to realize what they mean to each other. Addison has to make a decision.
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The residents determine their future as they make their final decisions regarding post residency positions; Mark admits to Derek that he is torn between his love for Lexie and the fact that Julia can give him everything he's ever wanted; Ben plans something extra special for Bailey, but she is preoccupied with her work; and Arizona encourages her childhood friend, Nick, to have surgery. Meanwhile a couple on their third honeymoon come to the hospital complaining of mysterious symptoms.
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Pete's decision about a patient has far reaching effects. Jake gives Amelia support to prevent her from misusing drugs again. Sheldon and Violet work together with a family troubled about the father's change in sexual appetite. Addison and Sam strive to figure out their situation.
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The residents agonize over their oral boards, reliving every answer they gave during their exams; Arizona's close childhood friend comes to Seattle Grace for medical help; the doctors work on a patient who is missing one third of his skull; and Julia asks Mark to start a family with her. Meanwhile Catherine tells Richard that one of his residents has failed.
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The team treats an illegal immigrant who self-induces her pregnancy which will allow her child be to be a U.S. citizen. Violet and Cooper help a young girl and her parents deal with her gender identity disorder. Before they start dating, Violet wants to continue therapy with Pete. Cooper continues with Mason's abrupt attitude towards him.
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Violet and Pete decide to give counseling a try. Amelia receives some news that causes her to retreat from her colleagues. Addison fine tunes her life to let in a new man. Mason gives Charlotte and Cooper cause for worry. A relative of one of her patients makes Violet suspicious.
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Cooper and Charlotte try to prepare Mason for the inevitable when Erica's medical condition quickly deteriorates. Violet and Pete discover they still have feelings for each other. Addison urges Amelia to welcome her pregnancy. Sheldon and Jake work with a pregnant woman who is in jail for killing two of her children.
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When Sam insists Corinne be released from the hospital to his care at home, Sheldon warns him he's in over his head. Pete treats Scott when he shows up in the ER badly beaten. Amelia has to decide what to do with her pregnancy. While visiting his daughter at college, Jake gets the third degree about his love life. Erica's health takes a down turn.
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Corinne's mental condition is making it close to impossible for Sam to take care of her. Amelia has news that will alter her life in a substantial way. Addison and Jake continue their playful exchanges. Cooper refuses any ideas to seek outside help for Erica's care.
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Cooper and Charlotte take Erica to Seattle Grace, Derek, Amelia and Lexie then explain the procedure that could save her life. Scott wants to advance his relationship with Violet. When Sam and Jake argue about a patient, Addison is caught in the middle. Erica explains to Mason about her tumor, who starts to get scared his mother might die and runs off. Sheldon offers some advice to Sam regarding his sister, Corinne.
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In her progress toward motherhood, Addison makes a decision on a sperm donor. Charlotte's past comes back to haunt her while Amelia's behavior continues towards recklessness. Cooper has to deal with parents who are giving their child drugs to control what they think is ADHD. Trust issues keep Pete from accepting Violet back into his life.
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In the first hour of the two-hour season six finale, Meredith receives life-changing news just as Seattle Grace Hospital is hit with a crisis like no other in its history.
This is the first hour of a 2-hour season finale. Two episode entries have been created. The 10pm EST marker will mark to beginning of the second episode.