In the mid 1950 as Lee Patrick was aging her acting career suddenly blossomed. He geared herself toward comedy eccentrics and was a hit. At this time she was won the role of Henrietta Topper, the flighty, quivery-voiced wife of Leo G. Carroll on the popular ghostly sitcom "Topper" (1953). There would be other fun and fluttery turns in Pillow Talk (1959) and 7 Faces of Dr. Lao (1964).
Lee Patrick got an RKO contract in 1937 which lead to steady secondary film work. In the 1940's she had became an invaluable Warner Brothers stock player enhancing such movies as "The Sisters" (1938), "Saturday's Children" (1940), "Dangerously They Live" (1942), "Now, Voyager" (1942), "Mrs. Parkington" (1944), and "Mildred Pierce" (1945).
Lee Patrick was a popular presence in New York during the 1920s and early 1930s. She received such scene-stealing roles as "June Moon," "Little Women," "Blessed Event" and "Stage Door."