Luis was nominated for a SAG Award in 1998 for the movie Boogie Nights. The category was Outstanding Performance by a Cast in a Theatrical Motion Picture. He was also nominated for a SAG award in 2000 for the film Magnolia in the same category. In 2001, he won the SAG Award for Outstanding Performance by a Cast in a Theatrical Motion Picture for Traffic.
Luis is of Puerto Rican descent.
Luis prefers his first name pronounced "Loo-ee".
Luis had a featured part in his high school play of Bye Bye Birdie.
Luis performed street theater while in college.
Luis graduated from City College of New York.
Luis has been married since 1985, and has five children. Four adopted, and one of their own.
Luis made his television debut in an episode of Miami Vice.
Luis was a social worker before he was an actor.
Luis won Best Supporting Actor at the Imagen Foundation Awards, for his role in Punch-Drunk Love.
Luis was the only actor with a major role to appear in both Carlito's Way, and its prequel Carlito's Way: Rise to Power.
Luis voiced the character of "Ricardo Diaz" in Grand Theft Auto: Vice City, and then reprised his role again in Grand Theft Auto: Vice City Stories.
Luis' favorite actor is Marlon Brando.
Luis is regularly cast in films by Brian DePalma, Paul Thomas Anderson, and Steven Soderberg.
Luis owns the ranch Wild Orchard Stables.
Luis is 5' 7 1/2" (1.71 m).
He often plays a cop or a villains' sidekick.
[On how he got into acting]
Luis Guzman: It was a fluke, man. I was walking down the street on the lower east side, minding my own business, a guy came up to me and said, "This is a phone number, call it up, maybe you could get a role", Next thing I know, I'm co-starring on Miami Vice. Had no clue what I was doing. I was doing it for six years after that as a way of making extra money–I was a social worker in New York's Lower East Side. And that's how I became an actor. It wasn't something I was looking for, man.
[On his role in The Count of Monte Cristo]
Luis Guzman: They could have gotten some theater-trained actor from England for that role. But they got me. I guess they figured it could work.
[On the director of his high school play Bye Bye Birdie]
Luis Guzman: I walked in on the auditions and said, 'Dude, you can't even run a gym class–how you gonna direct a play?' He threw the script at me and said, 'Well, then, let's see what you can do.'