Luke was chosen as one of People magazine's 'Sexiest Men Alive' for 2007.
Luke was blacklisted and banned from the Playboy mansion, after once trying to get into a party by pretending to be his brother, Owen.
Luke is of Irish descent and is the son of Robert and Laura Wilson. His father is an advertising executive and his mother is a photographer. Owen's two brothers, Owen and Andrew, are also actors. All three boys share the same middle name: Cunningham.
Luke is a member of the Bel Air Country Club in Los Angeles, California.
Luke's brother Owen has stated that he thinks of him as more of a 'Felix' from The Odd Couple, as he is touchy about his things.
Luke is 6 feet tall.
Luke's nicknames are "L-Train" and "One-Take Wilson."
Luke attended St. Mark's High School in Texas, where he still holds the school records for the 400 meter and 800 meter runs. He excelled at track and field while also attending Occidental College.
Luke is an avid golfer. He says that he has lots of fundamental problems with his game, but he can usually get it together and make a decent score. He also says that the best celebrity golfers are Mark Wahlberg and Bill Murray.
Luke: I'm going to be 37 next week. Do we have a biological clock, guys? I feel like I do. Something is definitely ticking.
Luke: I remember as a kid my older brother Owen telling me that if I folded down the waistband of my underwear and wore them on the outside, people would think I was wearing a bathing suit. So I did it, but I don't remember anyone thinking it was a bathing suit.
Luke: (on what makes him laugh) I can go for real dry humor, or I can go for super goofy. I know the best times I've had in the business are being around people like Will Ferrell, genuinely funny people who make you want to kid around.
Luke: (When told that he seems to be cast as the sort of guy whose shoulder girls cry on) Well, I am a solid guy. That seems to be something I've been saddled with in Hollywood, not that that's a bad thing. But I have had people I've gone out with say, 'You're not as nice as you are in the movies. You're nothing like the guy in Legally Blonde, you're actually a jerk'. And I've said, 'That's life'. Nah, it's just something I've ended up doing.
Luke: (When asked if he'd ever gone to a girl's house and had her parents react badly) I like to put my best foot forward and be funny and say something… and then realise it's offensive, try to explain it, and dig myself a deeper hole and finally there I am at the dinner table in a horrible mistake. But I've never had it happen too badly. I have had a few dads take me aside and tell me they love their daughters very much and what am I getting at?
Luke: (revealing he acts drunk so well by actually drinking) There's a fine line between being sloppy and just feeling relaxed. If you're doing a drunk scene all day, you can't start drinking at eight in the morning and keep it up till eight at night. But those last three hours? That's when I tell the director to shoot my close-up, because I'm gonna be bombed.