Meredith keeps herself busy while Derek prepares for his move; Jackson and April get difficult news; Arizona and Amelia talk about how best to approach Dr. Herman.
When the lead in the local theater production dies, the CBI is called on to investigate. Jane is determined to question comatose Jason Lennon about Red John.
Captain Matthew Gideon is assigned to the prototype destroyer Excalibur, to spearhead the search for a cure to the plague unleashed by the Drakh. His first mission is to seize a downed Drakh space craft on Ceti 4.moreless
The renegade destroyer Alexander arrives at Babylon 5 and Sheridan is forced to announce the station's secession from the Earth Alliance, and prepare for an attack by Clark's forces. Meanwhile, Delenn is forced to go to Minbar when the Grey Council refuses to act upon increased Shadow activity.moreless