As Leonardo tries to cross the Atlantic, without the aid of maps, Lorenzo's makes an undercover trip to Naples. Meanwhile, Lucrezia attends a secret meeting at the Vatican.
While Pope Sixtus's sanctions against Florence forces Lorenzo to make sacrifices, Leonardo continues to search for the Book of Leaves and Lucrezia seeks out new allies in Rome.
When Pope Sixtus tries to unite powers against Florence, Leonardo must come up with a solution. Meanwhile, Riario continues to tempt Nico.
With the House of Medici weakened, the Pazzis try to seize power in Florence, leading to Leonardo making a desperate gamble. Meanwhile, Count Riario believes he is getting closer to the Book of Leaves.moreless
Mitchell becomes so angry that his friends fear they must save him from himself. However, they will need saving themselves from Professor Jaggat's experiments.
Nina returns, throwing George into confusion, while Kemp offers to help Annie pass to through the door. Mitchell finds out about the truth of the vampire massacre and swears revenge on Lucy.
Sam puts George on the spot while Lucy reacts to sleeping with Mitchell. Annie helps a charlatan and ends up getting personally involved.
George and Mitchell continue their respective relationships with Sam and Lucy while Annie is thrown into the world of motherhood when she is left to look after a baby ghost.
Annie finds herself a new friend who agrees to help her keep death at bay. Mitchell finds himself slipping further into the darkness when his vampire controlling plans take a turn for the worse, meanwhile George tries to put Nina in the past and finds himself a new girlfriend.moreless
Depressed by Nina's leaving him, George attempts to take his mind off it by helping Annie. Mitchell attempts to form order within the vampire community which has been in chaos since the death of Herrick, Meanwhile Nina makes a decision she may regret.moreless
An old troubled friend pays Mitchell a visit, but is he willing to help. George and Nina continue to argue bringing another stress into their relationship and Annie beings to obsess about Saul believing he may be the man of her dreams but something is coming to haunt Saul and it is not Annie.moreless
Mitchell, George and Annie find themselves being tracked by two mysterious strangers, a Professor Jaggat and Kemp, after finding out that Vampires, Werewolves and Ghosts exist, they will do anything in their power to rid this world of such abominations. Meanwhile Annie who is now in control of her visibility to humans, decides to get a job, and George is finding it hard to cope with his involvement in the death of Herrick.moreless
Herrick missed his aim and Mitchell is still alive, so his only option is to face Herrick one on one to stop the suffering and end the imminent rising of the vampires. Meanwhile Annie has a difficult decision to make.moreless
Mitchell has rejoined the ranks of the vampires and is on board to recruit humans to increase their numbers.
Annie wants to make Owen pay or confess and she tries to scare him but Owen does not react like any normal person would. As for George, he's trying to help her out in any way he can.
Mitchell makes the acquaintance of a 12-year old and his mother. Bernie reminds him of his own childhood. However, things take a turn for the worse when the kid accidentally stumbles upon something he shouldn't see. As for George, he decides to tell Nina of his status as a werewolf. Annie tries to deal with what she learned about Owen.moreless
Annie is taken to a bar by Mitchell and George to try and cheer her up on what would have been her wedding day. They introduce her to another ghost named Gilbert who died in 1985; together they try to figure out why she's trapped in limbo. Meanwhile Lauren won't leave Mitchell alone and George finds out that a nurse at work named Nina has taken a shine to him.moreless
Mitchell decides to invite the neighbours around for some tea and chat to try and make them feel like they are part of the community and to feel human. George gets a visit from a werewolf named Tully who tries to be the friend that George has always wanted until he makes a confession about his real reasons for finding George. Meanwhile Mitchell resists his urges for blood and Herrick discovers where they live.moreless
The 3 housemates are discovering the difficulties of living in the human world, with vampire Mitchell struggling to repress his desire for blood, ghost Annie being confronted by another ghost from her past, and werewolf George looking for a place he can undergo his transformation in safety.moreless