In July 2009, Maura underwent surgery to remove a tumor from her breast after she suddenly fell ill on Friday, July 10, 2009.
In 2008, Maura was listed fifth in Forbes' list of "Prime-Time TV's 20 Top-Earning Women," with earnings for fiscal year 2007-2008 totaling $7.5 million.
Maura ranked No.57 in AfterEllen.com's Hot 100 List of 2007. She was at No.77 in 2008.
As of 2008, Maura divides her time between New York and Los Angeles.
Maura started acting as a teenager when she joined the Boston Globe Drama Festival in high school.
According to a 2002 interview in the Boston Phoenix, the medical term Maura had the most difficulty saying on ER was "Ceftriaxone," a broad-spectrum cephalosporin antibiotic.
In 2002, Maura was dubbed as "It Spongebath Hotpants" in Entertainment Weekly's annual IT list.
In a February 2002 interview with the Boston Phoenix, Maura stated that if there was one villain role she would like to play, it would be that of Heidi Fleiss, a former American prostitution ring owner and operator who was convicted and imprisoned for tax evasion.
In 2001, Maura was nominated for a Screen Actors Guild Award in the category of Outstanding Performance by an Ensemble in a Drama Series (ER).
Maura's pug, Rose Kennedy, is like a child to her and goes everywhere with her.
According to her NBC biography, Maura enjoys driving cross-country and has been through every state except Kansas and Iowa.
Maura once lived in New York's Hell's Kitchen and sold t-shirts door-to-door in college dormitories.
Though they have the same last name, Maura is not related to the late actress Gene Tierney.
According to an article in the April 1997 issue of Movieline, Maura suffers from recurring insomnia.
Maura is of Irish Catholic descent.
Maura was contacted by ER producers for the role of Abby Lockhart, which she got without having to audition.
Maura was nominated for a 2001 Emmy Award in the category of Outstanding Supporting Actress in a Drama Series for her portrayal of Abby Lockhart during Season 7 of NBC's medical drama ER.
Although Dr. Abby Lockhart, Maura's character on ER, was pregnant during the latter half of Season 12 (2005–2006), Maura herself was not expecting at the time.
Maura's father, Joseph Tierney, was at one time the president of the Boston City Council. Maura was seven years old when her father sat on the council. She used to go to the City Hall and also help during the campaign period.
Maura and Billy's black pug, Rose Kennedy, was named after the Kennedy matriarch in hopes that their dog would also have a long lifespan. (The View; January 12, 2005)
Maura became the champion of Bravo's 2004 Celebrity Poker Showdown, hosted by former NewsRadio co-star Dave Foley, when she beat Lauren Graham at the final table. She won $100,000 for the Children's Aid Society Carrera Adolescent Pregnancy Prevention Program in New York City.
Maura wrote a wry article about her world view, titled "Rudy Giuliani: A Fascist? You Be the Judge," for the 2001 spring issue of Flaunt magazine.
Maura is 5' 3½".
Maura diagnosed her husband's appendicitis attack using her ER textbook.
The day before shooting began, Maura was added to the cast in a comedy pilot called The Station, which was later renamed NewsRadio.
Maura met actor/director Billy Morrissette in 1988 after both of them were fired from the production set of the TV sitcom The Ralph Macchio Project (the series never did get off the ground). They were married in 1994. The two separated in March 2006. Maura filed for divorce in July of that year, citing irreconcilable differences.
Maura: I cry a lot when I try to quit smoking. It's horrible. At work nobody knows how to deal with me. They'll be like "Action!", I start weeping... it's hard. (The Late Late Show with Craig Ferguson; May 14, 2008)
Maura Tierney: (on getting the role of Pat McBeth in "Scotland, Pa.", directed by her husband) My line is that I not only had to sleep with the director, I had to sleep with him for 10 years. That's the longest casting-couch session ever. (SFGate, February 10, 2002)
Maura Tierney: I mean, I'm always wary about saying there's no great roles for women. I guess it's true and it's not true. It is the marketplace. Which is a little bit sad, in terms of what studios decide people will think is funny. I think the decisions about what entertains people are made before they know what entertains people. Now it seems really, really about the bottom line. But there is also new media! And it's easier than ever to make a movie now... If I'm frustrated, I should write a movie or shoot a movie. And 25 years ago you couldn't. (Los Angeles Times; March 2, 2008)
Maura Tierney: I prefer living in New York over Los Angeles, or for that matter, any other city I've visited.
Maura Tierney: (on the expectation that actresses must look good) It's part of the culture, it's part of the game, because the business is about selling. It's about perception, and if you can sell the perception, you can do well just based on how you're perceived. Talent sometimes isn't in that equation. Unfortunately, young actors learn this all too quickly.
Maura Tierney: (about how her and Billy Morrissette got together) It was during an earthquake. All the lights went out and we got tossed together and that's when we finally got passionate. It took a force of nature to get our romance going. (Late Night with Conan O'Brien)
Maura Tierney: So here's my "World View": There seems to be a Starbucks just about everywhere! (from Maura's essay "Rudy Giuliani: A Facist? You Be The Judge," Flaunt magazine, Spring 2001)
Maura Tierney: I diagnosed my husband's recent appendix attack. At first, he didn't believe me. He was having pain in his lower abdomen and felt nauseous. He also had a fever which I said was suspicious. I even did a stomach press check and I knew. Still, I got out my medical textbook they gave me on ER and said, "Let's go to the real doc." He said, "It's just the flu." Of course, they admitted him and took out his appendix. Now he's like, "Get over yourself. You're still not a real doctor."
Maura Tierney: I have so many insecurities they fight for prominence. (Emmy, 2001)
Maura Tierney: But my husband, I guess, happened to view me as the perfect manipulative, scheming, murderous bitch. (The View)
Maura Tierney: I don't think there's anything particularly innocent about me. (Newsweek)
Maura Tierney: I am not one of those crazy dog people. Except I think I might be, but I say I'm not. (The Rosie O'Donnell Show)
Maura Tierney: (about her husband (at the time) Billy's appendicitis) But in all fairness to him, I wanted him to be better in a few days after having this horrible surgery. I was like, 'What are you still doing on the couch?' I don't have much patience with sick people. (Women's Health, November/December 2005)