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Mellisa played a dual role, as Kay Howard's sister Carrie, at Meldrick Lewis's wedding in "The Wedding" episode of Homicide. This was speculated on at great length and later confirmed by a fellow cast member.
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One of the reasons Melissa left the ABC show The Young Riders was over a prop. According to Miss Leo, an episode dealt with her character, Emma, and a stolen pocket watch that had been her father's and was the only thing from her former life that Emma had taken west with her. Josh Brolin's character recovers it for her. The next week she asked the producers if she could wear the pocket watch and was informed that it had already been sent back to the rental house, In her own words, "That was really painful and lost me the job eventually."
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Miss Leo won the role of Linda Warner on the ABC soap All My Children for the 1984-'85 season, beating out, among other actresses, Julia Roberts.
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Melissa was a member of the cast of Tommy Lee Jones's The Three Burials of Melquiades Estrada, which won the Western Heritage Award Outstanding Theatrical Motion Picture in 2006.
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Her personal and legal problems with ex-lover John Heard were suspected by many in the industry as one of the reasons she did not return to Homicide: Life on the Street after the cast shakeup before the 1997 season.
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She appeared opposite Christopher Walken off-Broadway in Cinders.
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On stage Melissa has appeared in the New York Shakespeare Festival production of DON JUAN.
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Her role on All My Children earned her a Daytime Emmy Award nomination in 1985.
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Melissa studied at State University of New York, Purchase but did not graduate.
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Following their breakup Melissa was harassed in person and by phone by ex John Heard, who was officially charged in March 1997.