The Governor tries to get information out of Glenn and Maggie. Michonne arrives at the prison.
Rick continues to struggle after the death of Lori while Glenn and Maggie go for a supply run. Andrea grows closer to the Governor.
The group is severed and lives are put in jeopardy. In Woodbury, Merle has a request for the Governor.
Due to an unexpected death from the previous episode, the group decides to get organized and secure the farm. A final confrontation between Rick and Shane is put into motion.
After the destruction of his family, Herschel demands that Rick and his group leaves immediately. Shane and Rick's differences begin to openly erupt.
The secret of the Walkers in the barn is fully exposed and Shane forces a decision to be made about them. Herschel has given Rick an ultimatum that his group must leave.
Revelations begin to come out among the members of the group. Shane teaches Andrea how to fire a weapon but the desire to put the past behind him and focus on survival eats at him. Glenn wrestles with keeping his secret about the barn Walkers from the group. Lori confides in Dale about her pregnancy.
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The survivors have to deal with a huge walker that has fallen into one of the Greene Family's wells. The search for Sophia continues with Daryl finding a sign. Glenn and Maggie go into the town for some supplies, but end up doing more than just scavanging for medicine.Rick and Hershel have a discussion over God's role in the world and about how long Rick's group can stay at Hershel's farm. Finally, Lori asks Glenn to bring her a special item which could have grave effects on her family.
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The Greene Family and the Grimes family wait for Otis and Shane to return with the medical supplies for Carl. Meanwhile, Shane and Otis find themselves trapped in a school with hungry walkers waiting to eat them. Finally, Daryl and Andrea continue the hunt for Sophia.
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Desperate to find help for Carl, Rick heads for Hershel's Farm. Meanwhile, the rest of the group continues to hunt for Sophia in the woods. Finally, Shane and Otis head into the nearby town to scavange supplies in order to save Carl's life.
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Rick leads the group out of Atlanta. On the highway, they are stopped by a threat unlike anything they have seen before. The group searches for someone who has gone missing.
An odd scientist lets the refugees into the Center for Disease Control. While they stay at the facility, everything seems peaceful, despite the events going on throughout the outside world. However, peace cannot last forever.
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The group is led by their newest member to the Center for Disease Control while one of the members is forced to make a choice that has harsh consequences.