Michael McMillian was born October 21, 1978 in Olathe, Kansas. He grew up in Kansas City, and attended Blue Valley Northwest High School. He never classified himself as a "full-on nerd", but he loved comic books and hated sports. He claims that he was picked on in high school. He is a graduate of the Interlochen Center for the Arts, where he attended his junior and senior year of high school. He also studied at Carnegie Mellon University. He was spotted by an agent and signed on after a showcase audition at Carnegie.
Michael garnered national attention for his starring role in the independent film, Dorian Blues. Michael is probably best known for his recurring role as Henry on the now-cancelled WB television series, What I Like About You. Michael currently lives in Los Angeles.