Monica credits her friend Jason Douglas for pushing her into the voice acting business while she was still doing mostly stage acting, and some of her friends had gotten work at ADV Films.
Not only does Monica voice anime characters for ADV Films, she also writes articles for the US version of the anime magazine Newtype.
When asked in an actor commentary about which anime world she would like to be stuck in, Monica mentioned she would pick Tsubasa: RESERVoir CHRoNiCLE because "all the characters are tall and skinny." She also likes that the characters are also drawn well and change costumes, "not like Judy Jetson going to the sock hop."
In an actor commentary for Tsubasa: RESERVoir CHRoNiCLE, Monica mentions she initially was asked to audition for the mascot character Mokona over the Internet, but then she researched the other characters and fell in love with Sakura. She ended up auditioning for both, and landed the role of Sakura.
Monica Rial lends her voice to the character Ryoko in the show Jigoku Shoujo (aka Hell Girl).
According to her video interview on Noir, Monica mentions she was probably chosen to voice Chloe because the director wanted her to play a quiet role.
She not only appears in anime with fellow voice actors Chris Patton and Greg Ayers but the three are well known for being on stage together.
Monica has two brothers.
Monica describes her character, Aya Sugita on Kodocha, as "like Amy from Case Closed but quieter". Amy is a girl that hangs out with the main character Conan as they do detective work. Likewise, Aya is Sana's best friend.
Monica enjoys attending the anime conventions and likes when the folks cosplay, that is, dress up as different characters from the series she's in.
Monica initially auditioned for the starring role of Sana Kurata in the TV series Kodocha but ended up playing Sana's best friend, Aya.
On the Kodocha Volume 4 DVD audio commentary, Monica talks about driving around her 1982 Ford Probe.
When talking about her character, Saki from Steel Angel Kurumi, Monica states, "The roles that I've done, I've really enjoyed everything. But in particular, this character I wanted to play because there was that different angle. I believe my exact words were 'I want to play the lesbian!'"