While she was born in New York, New York, Nancy considers herself a native of Hackensack, New Jersey. Her father, a writer for Red Skelton, moved his family to Hollywood when Nancy was only 13 years old. And it wasn't long before young Nancy was bitten by the showbiz bug. She acted in plays and had a dancing career before appearing in films and on television.
Her first break came when she performed in Francis Ford Coppola's "One From the Heart." Next came an appearance on the long-running daytime drama "Days of Our Lives", and in such feature films as "One Dark Night," with Meg Tilly. After her work on the Emmy-nominated miniseries "In a Child's Name," with Valerie Bertinelli, McLoughlin became a highly visible and respected actress in numerous television movies. She had a series of outstanding and memorable roles in the films "Something to Live For: The Alison Gertz Story," "The Fire Next Time," "The Yarn Princess," "The Third Twin," with Kelly McGillis.
In 1984 she married Tom McLoughlin, and she often acts in films that he has either written or directed. One example of that would be "Friday the 13th Part 6: Jason Lives".
Together they have two children, a son and a daughter.