Nathan has twice played the role of a maternity doctor. Once was when he played Dr. Adam Mayfair on Desperate Housewives and once when he played Dr. Pomatter in the 2007 flick, Waitress.
Nathan was engaged to actress Vanessa Marcil in the 1990's. Even though they are no longer a couple, the two have remained friendly through the years. Vanessa even mentioned in her speech at the Emmy Awards that he was the person who had helped her through tough times and gave her the strength she needed to get through them.
Nathan appeared in an episode of the popular TV show, Lost, in an episode entitled I Do. In both this episode and the Firefly episode Our Mrs. Reynolds, Nathan plays a man who marries a woman whose true name he does not know and is later drugged by his wife and passes out. Neither of his characters' marriages lasted long.
During the filming of the fight scene between Mal and the Operative in the film, Serenity, Nathan repeatedly slammed his face into the Plexiglas floor to make it look more real. As a result, his left cheek became swollen. Nobody realized this until his make up was being touched up by the make-up artist.
Nathan's recent film, Slither, did not earn its budget at the box office. The film earned 12.2 million US dollars worldwide, but the total budget (including marketing) was 29.5 million US dollars.
When Nathan won best actor at the 2006 SyFy Genre Awards for his portrayal of Captain Malcolm Reynolds in Firefly, the show had been off the air for around 3 years.
Nathan has lived in Los Angeles since 1996.
While working in the Edmonton Fringe Festival, Nathan was part of the Rapidfire Theatre company and also worked on a soap opera parody production entitled Die Nasty.
Nathan Fillion was originally discovered performing in Edmonton's fringe theatre festival which led to his first big break with the part of Joey Buchanan in the soap opera One life to Live.
At the age of 12, Nathan had corrective eye surgery.
Nathan worked as a Karaoke presenter. His signature tune was Beyond the Sea.
Sometimes, Nathan wears a kilt.
Nathan's parents, Bob and Cookie, are high school English teachers and his older brother, Jeff, is a high school principal.
Nathan has a tattoo of an Egyptian glyph on his right hip.
Nathan was trained to be a teacher, but left four months before qualifying.
Nathan's worst Firefly moment was when everyone found out it was going to be cancelled because "it was just so not right and so unfair."
Nathan's favorite cheese is medium cheddar.
Nathan's first role on a major television series was that of Joey Buchanan on the soap opera entitled One Life to Live.
Nathan moved to New York City in 1994.
From a line in the series Firefly, Nathan is often referred to by fans as Captain Tightpants.
Nathan originally planned to be a High School English teacher, like several other members of his family. He majored in Art and minored in Drama to round out his curriculum. However, when he started acting on the side to help pay for school he was hooked.
Nathan won the Cinescape "Genre Face of the Future Award" in 2003 for his portrayal of Macolm Reynolds on Firefly.
In Firefly, Nathan did his own stunts, getting multiple bruises and a sprained ankle.
One of Nathan's past jobs was to sing telegrams.
Nathan is the voice for Gao the Lesser in the video game Jade Empire.
In 1996, Nathan was nominated for a Daytime Emmy Award in the category of Outstanding Young Actor.
Nathan is one of three actors, along with Adam Baldwin and Gina Torres, to cross over to either Buffy the Vampire Slayer or Angel after Firefly was canceled to play a 'Big Bad'. He played Caleb, the evil preacher, in Season 7 of Buffy the Vampire Slayer.
Nathan is 6' 1" (1.85 m) tall.
Nathan Fillion: I also have a cat. I'm not a cat-person, but she came with the house that I'm renting. I was told she was 18 when I moved in, so I thought, 'How long can she possibly last?' And that was 6 years ago – and I don't know how many hundreds of dollars worth of bump removals, teeth removals, cleanings and vet fees I have been through since then. But of course I love her and she is worth it.
Nathan Fillion: (on Firefly fans' attempts to save the show) It's very Jehovah's Witness. I'm not sure if anyone's actually going door to door, but it's not far off.
Nathan Fillion: (on Serenity) I want it to lead to a trilogy, because I want to do this again.
Nathan Fillion: (about Joss Whedon) One hundred percent of the time his idea makes me look cooler.
Nathan Fillion: (when asked about his relationship with Joss Whedon) I'll tell you this. No one has ever shown the kind of faith in me that Joss Whedon has shown, in both giving me a lead on his sci-fi show Firefly and in letting me play a villain for the very first time. No one's ever let me play a villain before. So, I would say that I think he's done great things for my career and certainly my confidence in general.
Nathan Fillion (about Serenity): There is nothing like a major motion picture to make you feel a little bit better about having your TV show canceled.
Nathan Fillion (when asked what he likes about playing a villain): Being able to be evil. You can't do the evil things that you want to do in real life. You certainly can't because it's against the law and society says all that they have to say about being evil. You want to be bad everyday. You want to do the bad evil things that you can't get away with and now I'm able to be bad and super strong. It's a fantasy.
Nathan Fillion (when asked what makes Caleb unique and threatening): His accent. Never trust a southerner. No, I'm kidding. They're wonderful. You want to believe in his niceness and his charm, but he's an evil kind of crazy man who's righteous. Fear the righteous.
Nathan Fillion: My favorite villains are the ones you don't see coming. What I enjoyed about playing Caleb was that he was so very, very clever, so very, very sweet, and so very, very twisted. I liked that he's not a typical villain. He's soft and sweet and righteous, and yet he's perverted and twisted in his head.
Nathan Fillion (talking about the cancellation of Firefly): I broke the cardinal rule of don't fall in love with what you're doing, because the rug can get yanked out from underneath you, and when it did, I was heartbroken.
Nathan Fillion: (responding to a question about his underwear) Same as every other man out there. They are old, got holes, and worn through to the point of transparency. I occasionally buy new ones but I never throw any away. If a man says he throws out his underwear, he is lying. It's as simple as that. They don't get trashed, they just sometimes fall off or ignite.