No one was surprised when the wealthy socialite and drug addict Vivian Bowers was found dead of an overdose, except for FBI agent Will Moreno. He is convinced that the death was a homicide, and that someone in Vivian´s family did it. He gets help from Detective Joanna Locasto, who at one point had been Vivian´s best friend. When Joanna attends the funeral, the family embraces her, offering her a place to stay. She then begins to undercover secrets about how Vivian died, putting herself in danger.
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When evidence surfaces in form of several pictures at a crime scene on the Brooklyn Bridge, the CSIs rush to San Francisco to search for a 16-year-old girl who might be dead already. The case hits home for Jo.
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The residents determine their future as they make their final decisions regarding post residency positions; Mark admits to Derek that he is torn between his love for Lexie and the fact that Julia can give him everything he's ever wanted; Ben plans something extra special for Bailey, but she is preoccupied with her work; and Arizona encourages her childhood friend, Nick, to have surgery. Meanwhile a couple on their third honeymoon come to the hospital complaining of mysterious symptoms.
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The residents agonize over their oral boards, reliving every answer they gave during their exams; Arizona's close childhood friend comes to Seattle Grace for medical help; the doctors work on a patient who is missing one third of his skull; and Julia asks Mark to start a family with her. Meanwhile Catherine tells Richard that one of his residents has failed.
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