Chicago Med is inundated with the victims of shooting at a movie theater, the shooter and the hero. Dr. Rhodes gets irritated by the general consensus that he should not try too hard to save the shooter's life, a teenage boy. Sharon Goodwin must manage the press and the internal dynamics of the situation. Dr. Manning treats a teenage girl, Ashley, for nausea and feels that there is concerns to consult Dr. Charles for a possible eating disorder. Dr. Charles employs an unusual method which raises concerns with both Dr. Manning and the patient's mother. Dr. Choi is asked to consult on a case involving a elderly woman who makes very racist statements.moreless
When Dr. Rhodes treats a man who was impaled, he reunites with his estranged sister, Claire and takes a look at his past. Dr. Halstead treats a young musician who needs surgery but it could cost her the ability to hear.moreless
Dr. Choi must put his personal feelings aside when treating a teenage mother who abandoned her newborn baby in an alley. Dr. Manning treats the abandoned baby and clashes with Dr. Choi about the mother. Dr. Charles assists Sarah Reeves in treating an elderly woman diagnosed with Dementia.moreless
The new team of doctors have a hand full when there's a train accident.
Jane is desperate to fix things with Rafael and suggests working on a way to help them move past their problems. Xo has been keeping a secret from Rogelio, but when she finally comes clean to him, Rogelio's reaction surprises her. Alba has a flashback of who pushed her down the stairs. Still dealing with the Sin Rostro aftermath, Michael makes an upsetting discovery about who was involved all along. Meanwhile, Petra finds herself in a dire situation leaving her to save herself.moreless
Rogelio's mom visits, but she and Xo are not on good terms. Meanwhile, Rafael gets news about his biological mother; Jane must miss her family's Easter celebration in order to fix a mishap she caused at work; and Petra seeks assistance from Michael.moreless
Jane considers attending a romance-writing workshop to get over a case of writer's block. Meanwhile, Rogelio asks to shadow Michael to gain greater insight into portraying a cop; Rafael must ask Rogelio for a favor; and a rift occurs between Xo and Alba.moreless
When an American woman is rescued from terrorist captivity, the team learn one of her captors was American. Gibbs and Fornell try to cope with their ex-wife's murder.
Don makes a new friend. Joan meets a client for drinks. Peggy hears impressive new work. Roger has a puzzling phone call.
A female car accident victim is brought to the ER, and the staff immediately blames her boyfriend for causing the accident, which stirs some painful memories for Will. Emily learns that her patient is refusing to undergo surgery to treat her cancer, fearing that reconstructive surgery will damage both her career and her relationship. Meanwhile, as Will prepares for an upcoming exam, he struggles to decide between using Cassandra's study method over Emily's legendary flashcards, which brings out Emily's competitive side.moreless
While investigating a boy's murder, the team allows Avalon Harmonia access to the body after she claims the boy's soul hasn't passed on. Avalon's work causes the scientists to reexamine what they believe about life after death.moreless
In the season finale the Graysons are continuing down a path of self-destruction, as Amanda fully intends to finally follow through with her plan for revenge, and an explosive event changes everything.