Castiel returns and asks Sam and Dean to help him against demons seeking Lucifer's Crypt. When they set out to take on the demons, they rescue Meg, who is being interrogated for information. While Dean and Castiel go to find the Crypt, Sam and Meg fight a rearguard action to hold Crowley off.
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The Winchesters and their allies, including Bobby, Castiel, Meg, and the Prophet Kevin, must try and stop Dick Roman and his Leviathans in a final showdown.
Meg summons Sam and Dean when Castiel wakes up. However, the brothers have other problems on their hands when they get word of a teenager who has been struck by lightning and become a prophet, and may hold the key to defeating the Leviathans.
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When Lucifer pays Sam another visit, he drives him to the brink, forcing Sam to enter a mental hospital. Fearing for his brother's life, Dean takes matters into his own hands, calling upon every hunter he knows. He receives the name of a healer from one hunter, only to find a familiar face waiting for him.
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The Machine gives Reese and Finch the number of a down-and-out man who has been pushed too far, and they're forced to turn to former Person of Interest Zoe Morgan for help.
SAMCRO's relationship with the Cartel is in jeopardy when an important package is compromised.