While Miller publishes a story that threatens to destroy Kane, he battles to stay on top, but is concerned over Doyle's alliance with Kitty.
As the city's emergency managers prepare to take over, Kane's enemies threaten to unseat him.
In order to keep his grip on Chicago, Kane finds he has no choice but to work with Alderman Ross.
Now that Kane's treatment seems to have worked, he must regain control of Chicago.
With riots breaking out at the housing project, Kane seeks treatment at an alternative clinic, but his past comes back to haunt him.
While the symptoms of his disease leave him unable to differentiate between reality and hallucinations, his hold over the City Council is threatened by his anti-corruption stance.
While his wife and daughter reject his efforts to reconnect, Kane streamlines his political staff.
Kane decides to redevelop a housing project, to get closer to Mona.
Needing to find a replacement for Stone, Kane hires an ambitious newcomer to the political scene and entices his adversary's aide.
Mayor Thomas Kane attempts to ignore the symptoms and hallucinations of his disease and concentrate on new enhancements to the terminals at Chicago airport.
Election day is finally here and as the candidates await the results, Kane and Stone must work behind the scenes to alter the political climate to their advantage. Meredith takes drastic steps to prove her allegiance to Kane while Emma's world comes crashing down.moreless
Kane races against the clock to repair his public image. Zajac and Meredith make their move against Kane with interesting results. Miller receives an unexpected offer.
With his political image at an all-time low, Kane takes an unexpected break from City Hall to visit an old friend. Meredith starts to question Tom's ability to weather this storm, and pursues interests of her own. Kitty makes a bold decision.moreless
After deeply buried information about his past comes to light, Kane and his staff attempt to manipulate the media by trying to control the tide of public perception.
Kane's political credibility comes into question as supporters start to lose confidence. Zajac attempts a bold move to further his campaign. Miller continues his search for answers.
Kane continues to have problems in managing his condition. Zajac's campaign starts to gain momentum. Miller discovers that his story might have more to it than meets the eye. Governor Cullen gets caught in the middle of an embarrassing media storm.moreless
With only a few weeks until the primary, the governor's race heats up as a new political force enters the scene. Kane uses his political clout to deflect stonewalling by the City Council. Meredith receives some unexpected information that makes her suspect Tom might have a secret.moreless
After being diagnosed with a degenerative neurological disorder, Chicago Mayor Tom Kane must set aside his personal issues as he attempts to run the city with an iron fist, while also dealing with the upcoming gubernatorial primary.moreless