In the Middle East, Willy and Barney infiltrate a chemical plant to gain access to Dehominant-B, a quick-acting lethal gas. Barney is exposed to Dehominant-A while trying to get to the computer and crippled - Willy escapes and Barney is captured. Barney is interrogated and only has four hours to live. The team find out that Dr. Jerry Carlin, a dropout, is the only other person with the skills to access the computer. When Carlin rejects the team's appeal for help, Doug and Paris frame Carlin's girlfriend and threaten to keep her in jail unless he helps them.moreless
Thrush agent Barnaby Partridge uses his island gambling casino to brainwash VIPs into committing suicide by playing on their secret fears. U.N.C.L.E. sends Taggart Coleman to the island to help Napoleon and Illya uncover the process, and he encounters an old love interest there, Monica. But Partridge takes Illya prisoner and subjects him to the process training him to kill Napoleon.moreless
Illya goes to find Thrush's vaporizing machine, but is captured by Sophie, the headstrong daughter of the local tribal chief, Sulador. In New York, Solo convinces retiring Thrush agent David Lewin that Thrush intends to kill him, and elicits his help. Lewin and Solo are taken to the base in the desert, just as Illya leads the band of nomads, whose confidence he has gained, in an attack on the base.moreless
After one of the biggest names in fashion is poisoned after embarrassing her husband on TV, the husband is considered the prime suspect.
Gunn is "sentenced" to death for the murder of a clerk, but he escapes jail.